Seroatlas · Human Serome Atlas

PRSS3P2

Putative trypsin-6

Also known as: TRY6_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHM4
Gene: PRSS3P2
Canonical length: 247 aa

OverviewNCBI Gene

No narrative summary is available for PRSS3P2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q8NHM4|PRSS3P2
     1  MNPLLILAFV GAAVAVPFDD DDKIVGGYTC EENSVPYQVS LNSGSHFCGG SLISEQWVVS
    61  AGHCYKPHIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN RIILNNDIML IKLSTPAVIN
   121  AHVSTISLPT APPAAGTECL ISGWGNTLSS GADYPDELQC LDAPVLTQAK CKASYPLKIT
   181  SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGIVSWGYGC AQKRRPGVYT KVYNYVDWIK
   241  DTIAANS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS3P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS3P2 as an antibody target. Whether an autoantibody or antibody against PRSS3P2 could matter depends on whether native PRSS3P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS3P2 is annotated as secreted, so native PRSS3P2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS3P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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