Seroatlas · Human Serome Atlas

PRSS38

Serine protease 38

Also known as: MPN2, PRS38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L453
Gene: PRSS38
Ensembl: ENSG00000185888
Chromosome: 1
Canonical length: 326 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>A1L453|PRSS38
     1  MAAPASVMGP LGPSALGLLL LLLVVAPPRV AALVHRQPEN QGISLTGSVA CGRPSMEGKI
    61  LGGVPAPERK WPWQVSVHYA GLHVCGGSIL NEYWVLSAAH CFHRDKNIKI YDMYVGLVNL
   121  RVAGNHTQWY EVNRVILHPT YEMYHPIGGD VALVQLKTRI VFSESVLPVC LATPEVNLTS
   181  ANCWATGWGL VSKQGETSDE LQEMQLPLIL EPWCHLLYGH MSYIMPDMLC AGDILNAKTV
   241  CEGDSGGPLV CEFNRSWLQI GIVSWGRGCS NPLYPGVYAS VSYFSKWICD NIEITPTPAQ
   301  PAPALSPALG PTLSVLMAML AGWSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

testis: 4.1 nTPM
choroid plexus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early primary spermatocytes: 47 nCPM
differentiating spermatogonia: 11 nCPM
medullary thymic epithelial cells: 9.6 nCPM
epicardial cells: 4.5 nCPM
retinal ganglion cells: 3.9 nCPM
epididymal basal cells: 2.8 nCPM

Immune cell

NK-cell: 0.4 nTPM
gdT-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM
cerebellum: 0.2 nTPM
spinal cord: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.08
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS38 as an antibody target. Whether an autoantibody or antibody against PRSS38 could matter depends on whether native PRSS38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS38 is annotated as secreted, so native PRSS38 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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