Seroatlas · Human Serome Atlas

PRSS37

Probable inactive serine protease 37

Also known as: PRS37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1T9
Gene: PRSS37
Ensembl: ENSG00000165076
Chromosome: 7
Canonical length: 235 aa
Protein class: Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Involved in positive regulation of acrosome reaction and regulation of protein processing. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>A4D1T9|PRSS37
     1  MKYVFYLGVL AGTFFFADSS VQKEDPAPYL VYLKSHFNPC VGVLIKPSWV LAPAHCYLPN
    61  LKVMLGNFKS RVRDGTEQTI NPIQIVRYWN YSHSAPQDDL MLIKLAKPAM LNPKVQPLTL
   121  ATTNVRPGTV CLLSGLDWSQ ENSGRHPDLR QNLEAPVMSD RECQKTEQGK SHRNSLCVKF
   181  VKVFSRIFGE VAVATVICKD KLQGIEVGHF MGGDVGIYTN VYKYVSWIEN TAKDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

testis: 39 nTPM
thymus: 0.4 nTPM
cerebellum: 0.2 nTPM
ovary: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM

Single-cell type

early spermatids: 820 nCPM
late spermatids: 426 nCPM
late primary spermatocytes: 19 nCPM
epicardial cells: 4.5 nCPM
adipocytes: 1.9 nCPM
sertoli cells: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.3 nTPM
white matter: 2.1 nTPM
midbrain: 1.7 nTPM
hypothalamus: 1.5 nTPM
thalamus: 1.5 nTPM
hippocampal formation: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS37 as an antibody target. Whether an autoantibody or antibody against PRSS37 could matter depends on whether native PRSS37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS37 is annotated as secreted, so native PRSS37 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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