Seroatlas · Human Serome Atlas

PRSS36

Polyserase-2

Also known as: FLJ90661, POLS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5K4E3
Gene: PRSS36
Ensembl: ENSG00000178226
Chromosome: 16
Canonical length: 855 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

Enables serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

855 residues, UniProt reviewed canonical sequence.

>Q5K4E3|PRSS36
     1  MARHLLLPLV MLVISPIPGA FQDSALSPTQ EEPEDLDCGR PEPSARIVGG SNAQPGTWPW
    61  QVSLHHGGGH ICGGSLIAPS WVLSAAHCFM TNGTLEPAAE WSVLLGVHSQ DGPLDGAHTR
   121  AVAAIVVPAN YSQVELGADL ALLRLASPAS LGPAVWPVCL PRASHRFVHG TACWATGWGD
   181  VQEADPLPLP WVLQEVELRL LGEATCQCLY SQPGPFNLTL QILPGMLCAG YPEGRRDTCQ
   241  GDSGGPLVCE EGGRWFQAGI TSFGFGCGRR NRPGVFTAVA TYEAWIREQV MGSEPGPAFP
   301  TQPQKTQSDP QEPREENCTI ALPECGKAPR PGAWPWEAQV MVPGSRPCHG ALVSESWVLA
   361  PASCFLDPNS SDSPPRDLDA WRVLLPSRPR AERVARLVQH ENASWDNASD LALLQLRTPV
   421  NLSAASRPVC LPHPEHYFLP GSRCRLARWG RGEPALGPGA LLEAELLGGW WCHCLYGRQG
   481  AAVPLPGDPP HALCPAYQEK EEVGSCWNDS RWSLLCQEEG TWFLAGIRDF PSGCLRPRAF
   541  FPLQTHGPWI SHVTRGAYLE DQLAWDWGPD GEETETQTCP PHTEHGACGL RLEAAPVGVL
   601  WPWLAEVHVA GDRVCTGILL APGWVLAATH CVLRPGSTTV PYIEVYLGRA GASSLPQGHQ
   661  VSRLVISIRL PQHLGLRPPL ALLELSSRVE PSPSALPICL HPAGIPPGAS CWVLGWKEPQ
   721  DRVPVAAAVS ILTQRICDCL YQGILPPGTL CVLYAEGQEN RCEMTSAPPL LCQMTEGSWI
   781  LVGMAVQGSR ELFAAIGPEE AWISQTVGEA NFLPPSGSPH WPTGGSNLCP PELAKASGSP
   841  HAVYFLLLLT LLIQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 2.4 nTPM
adipose tissue: 1.3 nTPM
skin: 1 nTPM
blood vessel: 0.9 nTPM
duodenum: 0.9 nTPM
adrenal gland: 0.8 nTPM

Single-cell type

enterocytes: 43 nCPM
hofbauer cells: 35 nCPM
colonocytes: 17 nCPM
pituitary stem cells: 15 nCPM
macrophages: 10 nCPM
paneth cells: 7.7 nCPM

Immune cell

eosinophil: 2 nTPM
neutrophil: 1 nTPM
myeloid DC: 0.7 nTPM
classical monocyte: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

thalamus: 0.8 nTPM
basal ganglia: 0.7 nTPM
cerebral cortex: 0.6 nTPM
pons: 0.6 nTPM
white matter: 0.5 nTPM
hippocampal formation: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS36 as an antibody target. Whether an autoantibody or antibody against PRSS36 could matter depends on whether native PRSS36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS36 is annotated as secreted, so native PRSS36 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...