Seroatlas · Human Serome Atlas

PRSS35

Inactive serine protease 35

Also known as: C6orf158, dJ223E3.1, MGC46520, PRS35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3Z0
Gene: PRSS35
Ensembl: ENSG00000146250
Chromosome: 6
Canonical length: 413 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted in female reproductive system

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

413 residues, UniProt reviewed canonical sequence.

>Q8N3Z0|PRSS35
     1  MENMLLWLIF FTPGWTLIDG SEMEWDFMWH LRKVPRIVSE RTFHLTSPAF EADAKMMVNT
    61  VCGIECQKEL PTPSLSELED YLSYETVFEN GTRTLTRVKV QDLVLEPTQN ITTKGVSVRR
   121  KRQVYGTDSR FSILDKRFLT NFPFSTAVKL STGCSGILIS PQHVLTAAHC VHDGKDYVKG
   181  SKKLRVGLLK MRNKSGGKKR RGSKRSRREA SGGDQREGTR EHLRERAKGG RRRKKSGRGQ
   241  RIAEGRPSFQ WTRVKNTHIP KGWARGGMGD ATLDYDYALL ELKRAHKKKY MELGISPTIK
   301  KMPGGMIHFS GFDNDRADQL VYRFCSVSDE SNDLLYQYCD AESGSTGSGV YLRLKDPDKK
   361  NWKRKIIAVY SGHQWVDVHG VQKDYNVAVR ITPLKYAQIC LWIHGNDANC AYG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

retina: 47 nTPM
ovary: 18 nTPM
basal ganglia: 8.6 nTPM
cerebral cortex: 7.5 nTPM
blood vessel: 6.3 nTPM
amygdala: 5.7 nTPM

Single-cell type

müller glia: 416 nCPM
granulosa cells: 28 nCPM
astrocytes: 13 nCPM
ovarian stromal cells: 10 nCPM
pericytes: 9.5 nCPM
peritubular myoid cells: 7.4 nCPM

Immune cell

MAIT T-cell: 20 nTPM
memory CD8 T-cell: 2.1 nTPM
gdT-cell: 1.2 nTPM
memory CD4 T-cell: 0.3 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

basal ganglia: 5 nTPM
cerebral cortex: 4.4 nTPM
amygdala: 3.1 nTPM
hippocampal formation: 2.9 nTPM
thalamus: 2.4 nTPM
white matter: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS35 as an antibody target. Whether an autoantibody or antibody against PRSS35 could matter depends on whether native PRSS35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS35 is annotated as secreted, so native PRSS35 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...