Seroatlas · Human Serome Atlas

PRSS33

Serine protease 33

Also known as: EOS, PRS33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NF86
Gene: PRSS33
Ensembl: ENSG00000103355
Chromosome: 16
Canonical length: 280 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Involved in proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q8NF86|PRSS33
     1  MRGVSCLQVL LLLVLGAAGT QGRKSAACGQ PRMSSRIVGG RDGRDGEWPW QASIQHRGAH
    61  VCGGSLIAPQ WVLTAAHCFP RRALPAEYRV RLGALRLGST SPRTLSVPVR RVLLPPDYSE
   121  DGARGDLALL QLRRPVPLSA RVQPVCLPVP GARPPPGTPC RVTGWGSLRP GVPLPEWRPL
   181  QGVRVPLLDS RTCDGLYHVG ADVPQAERIV LPGSLCAGYP QGHKDACQGD SGGPLTCLQS
   241  GSWVLVGVVS WGKGCALPNR PGVYTSVATY SPWIQARVSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 4.6 nTPM
salivary gland: 0.9 nTPM
small intestine: 0.8 nTPM
appendix: 0.6 nTPM
stomach: 0.5 nTPM
duodenum: 0.4 nTPM

Single-cell type

retinal pigment epithelial cells: 111 nCPM
fallopian secretory cells: 24 nCPM
epididymal efferent duct absorptive cells: 15 nCPM
lacrimal acinar cells: 1.8 nCPM
submucosal glandular cells: 1.2 nCPM
gastric chief cells: 1.1 nCPM

Immune cell

eosinophil: 1,353 nTPM
basophil: 20 nTPM
NK-cell: 3.4 nTPM
neutrophil: 2.2 nTPM
total PBMC: 1 nTPM
classical monocyte: 0.4 nTPM

Brain region

white matter: 0.6 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

serine-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS33 as an antibody target. Whether an autoantibody or antibody against PRSS33 could matter depends on whether native PRSS33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS33 is annotated as secreted, so native PRSS33 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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