PRSS3
Trypsin-3
Also known as: PRSS4, TRY3, TRY3_HUMAN, TRY4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P35030
- Gene
- PRSS3
- Ensembl
- ENSG00000010438
- Chromosome
- 9
- Canonical length
- 304 aa
- Protein class
- Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Endoplasmic reticulum,Vesicles
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]
Canonical amino-acid sequenceUniProt
304 residues, UniProt reviewed canonical sequence.
>P35030|PRSS3
1 MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
61 DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
121 CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
181 STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
241 FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
301 AANSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRSS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 29,337 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 29,337 nTPM
- esophagus: 124 nTPM
- small intestine: 99 nTPM
- duodenum: 87 nTPM
- skin: 84 nTPM
- colon: 82 nTPM
Single-cell type
- pancreatic acinar cells: 9,292 nCPM
- esophageal apical cells: 4,351 nCPM
- enterocytes: 1,276 nCPM
- colonocytes: 1,197 nCPM
- gastric progenitor cells: 706 nCPM
- tuft cells: 427 nCPM
Immune cell
- basophil: 160 nTPM
- intermediate monocyte: 1.5 nTPM
- non-classical monocyte: 1.5 nTPM
- MAIT T-cell: 1.2 nTPM
- myeloid DC: 0.5 nTPM
- memory CD8 T-cell: 0.4 nTPM
Brain region
- cerebral cortex: 28 nTPM
- hypothalamus: 20 nTPM
- cerebellum: 20 nTPM
- pons: 20 nTPM
- hippocampal formation: 18 nTPM
- white matter: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRSS3 as an antibody target. Whether an autoantibody or antibody against PRSS3 could matter depends on whether native PRSS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRSS3 is annotated as secreted, so native PRSS3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PRSS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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