Seroatlas · Human Serome Atlas

PRSS27

Serine protease 27

Also known as: CAPH2, MPN, PRS27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQR3
Gene: PRSS27
Ensembl: ENSG00000172382
Chromosome: 16
Canonical length: 290 aa
Protein class: Enzymes, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q9BQR3|PRSS27
     1  MRRPAAVPLL LLLCFGSQRA KAATACGRPR MLNRMVGGQD TQEGEWPWQV SIQRNGSHFC
    61  GGSLIAEQWV LTAAHCFRNT SETSLYQVLL GARQLVQPGP HAMYARVRQV ESNPLYQGTA
   121  SSADVALVEL EAPVPFTNYI LPVCLPDPSV IFETGMNCWV TGWGSPSEED LLPEPRILQK
   181  LAVPIIDTPK CNLLYSKDTE FGYQPKTIKN DMLCAGFEEG KKDACKGDSG GPLVCLVGQS
   241  WLQAGVISWG EGCARQNRPG VYIRVTAHHN WIHRIIPKLQ FQPARLGGQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 374 nTPM

Expression across tissuesHPA

Tissue

esophagus: 374 nTPM
vagina: 125 nTPM
cervix: 101 nTPM
salivary gland: 47 nTPM
tonsil: 28 nTPM
cerebellum: 4.8 nTPM

Single-cell type

esophageal apical cells: 7,187 nCPM
esophageal suprabasal cells: 98 nCPM
suprabasal keratinocytes: 90 nCPM
salivary duct cells: 17 nCPM
esophageal basal cells: 11 nCPM
breast secretory cells: 10 nCPM

Immune cell

myeloid DC: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

midbrain: 2 nTPM
hypothalamus: 1.9 nTPM
thalamus: 1.6 nTPM
medulla oblongata: 1.4 nTPM
pons: 1.1 nTPM
cerebellum: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS27 as an antibody target. Whether an autoantibody or antibody against PRSS27 could matter depends on whether native PRSS27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS27 is annotated as secreted, so native PRSS27 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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