Seroatlas · Human Serome Atlas

PRSS23

Serine protease 23

Also known as: PRS23_HUMAN, SIG13, SPUVE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95084
Gene: PRSS23
Ensembl: ENSG00000150687
Chromosome: 11
Canonical length: 383 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a conserved member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels of this gene after ovulation was induced. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>O95084|PRSS23
     1  MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK PDFGAEAKLE
    61  VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYILSSSG DGAQHRDSGS
   121  SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF STSVKLSTGC TGTLVAEKHV LTAAHCIHDG
   181  KTYVKGTQKL RVGFLKPKFK DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND
   241  IGMDYDYALL ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE
   301  TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG SPQDFNVAVR
   361  ITPLKYAQIC YWIKGNYLDC REG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

cervix: 233 nTPM
blood vessel: 137 nTPM
seminal vesicle: 121 nTPM
smooth muscle: 108 nTPM
colon: 98 nTPM
urinary bladder: 93 nTPM

Single-cell type

respiratory secretory cells: 1,715 nCPM
conjunctival goblet cells: 1,401 nCPM
respiratory basal cells: 1,028 nCPM
adipocytes: 1000 nCPM
respiratory deuterosomal cells: 970 nCPM
decidual stromal cells: 581 nCPM

Immune cell

gdT-cell: 105 nTPM
memory CD8 T-cell: 60 nTPM
naive CD8 T-cell: 51 nTPM
total PBMC: 40 nTPM
NK-cell: 34 nTPM
memory CD4 T-cell: 18 nTPM

Brain region

thalamus: 28 nTPM
medulla oblongata: 27 nTPM
midbrain: 26 nTPM
choroid plexus: 24 nTPM
pons: 15 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

serine-type endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS23 as an antibody target. Whether an autoantibody or antibody against PRSS23 could matter depends on whether native PRSS23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS23 is annotated as secreted, so native PRSS23 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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