Seroatlas · Human Serome Atlas

PRSS22

Brain-specific serine protease 4

Also known as: BSSP-4, BSSP4_HUMAN, hBSSP-4, SP001LA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZN4
Gene: PRSS22
Ensembl: ENSG00000005001
Chromosome: 16
Canonical length: 317 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q9GZN4|PRSS22
     1  MVVSGAPPAL GGGCLGTFTS LLLLASTAIL NAARIPVPPA CGKPQQLNRV VGGEDSTDSE
    61  WPWIVSIQKN GTHHCAGSLL TSRWVITAAH CFKDNLNKPY LFSVLLGAWQ LGNPGSRSQK
   121  VGVAWVEPHP VYSWKEGACA DIALVRLERS IQFSERVLPI CLPDASIHLP PNTHCWISGW
   181  GSIQDGVPLP HPQTLQKLKV PIIDSEVCSH LYWRGAGQGP ITEDMLCAGY LEGERDACLG
   241  DSGGPLMCQV DGAWLLAGII SWGEGCAERN RPGVYISLSA HRSWVEKIVQ GVQLRGRAQG
   301  GGALRAPSQG SGAAARS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

esophagus: 78 nTPM
salivary gland: 26 nTPM
vagina: 24 nTPM
cervix: 20 nTPM
kidney: 10 nTPM
prostate: 5.9 nTPM

Single-cell type

esophageal apical cells: 151 nCPM
urothelial cells: 41 nCPM
conjunctival goblet cells: 27 nCPM
papillary tip epithelial cells: 24 nCPM
cytotrophoblasts: 21 nCPM
renal collecting duct principal cells: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
basal ganglia: 0.1 nTPM
spinal cord: 0.1 nTPM
amygdala: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 1.02
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS22 as an antibody target. Whether an autoantibody or antibody against PRSS22 could matter depends on whether native PRSS22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS22 is annotated as secreted, so native PRSS22 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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