Seroatlas · Human Serome Atlas

PRSS2

Trypsin-2

Also known as: TRY2, TRY2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P07478
Gene: PRSS2
Ensembl: ENSG00000275896
Chromosome: 7
Canonical length: 247 aa
Protein class: Enzymes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Subcellular location: Endoplasmic reticulum,Vesicles
Secretome location: Secreted to digestive system

OverviewNCBI Gene

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>P07478|PRSS2
     1  MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS
    61  AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN SRTLDNDILL IKLSSPAVIN
   121  SRVSAISLPT APPAAGTESL ISGWGNTLSS GADYPDELQC LDAPVLSQAE CEASYPGKIT
   181  NNMFCVGFLE GGKDSCQGDS GGPVVSNGEL QGIVSWGYGC AQKNRPGVYT KVYNYVDWIK
   241  DTIAANS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 229,146 nTPM

Expression across tissuesHPA

Tissue

pancreas: 229,146 nTPM
small intestine: 498 nTPM
duodenum: 337 nTPM
blood vessel: 61 nTPM
adipose tissue: 57 nTPM
stomach: 57 nTPM

Single-cell type

pancreatic acinar cells: 159,287 nCPM
paneth cells: 5,720 nCPM
pancreatic duct cells: 129 nCPM
gastric progenitor cells: 87 nCPM
mucous neck cells: 55 nCPM
foveolar cells: 51 nCPM

Immune cell

basophil: 4.1 nTPM
T-reg: 2.9 nTPM
memory B-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
total PBMC: 0.2 nTPM
classical monocyte: 0 nTPM

Brain region

basal ganglia: 0.5 nTPM
cerebral cortex: 0.4 nTPM
amygdala: 0.2 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS2 as an antibody target. Whether an autoantibody or antibody against PRSS2 could matter depends on whether native PRSS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS2 is annotated as secreted, so native PRSS2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRSS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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