Seroatlas · Human Serome Atlas

PRSS16

Thymus-specific serine protease

Also known as: TSSP, TSSP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQE7
Gene: PRSS16
Ensembl: ENSG00000112812
Chromosome: 6
Canonical length: 514 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q9NQE7|PRSS16
     1  MAVWLAQWLG PLLLVSLWGL LAPASLLRRL GEHIQQFQES SAQGLGLSLG PGAAALPKVG
    61  WLEQLLDPFN VSDRRSFLQR YWVNDQHWVG QDGPIFLHLG GEGSLGPGSV MRGHPAALAP
   121  AWGALVISLE HRFYGLSIPA GGLEMAQLRF LSSRLALADV VSARLALSRL FNISSSSPWI
   181  CFGGSYAGSL AAWARLKFPH LIFASVASSA PVRAVLDFSE YNDVVSRSLM STAIGGSLEC
   241  RAAVSVAFAE VERRLRSGGA AQAALRTELS ACGPLGRAEN QAELLGALQA LVGGVVQYDG
   301  QTGAPLSVRQ LCGLLLGGGG NRSHSTPYCG LRRAVQIVLH SLGQKCLSFS RAETVAQLRS
   361  TEPQLSGVGD RQWLYQTCTE FGFYVTCENP RCPFSQLPAL PSQLDLCEQV FGLSALSVAQ
   421  AVAQTNSYYG GQTPGANKVL FVNGDTDPWH VLSVTQALGS SESTLLIRTG SHCLDMAPER
   481  PSDSPSLRLG RQNIFQQLQT WLKLAKESQI KGEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 770 nTPM

Expression across tissuesHPA

Tissue

thymus: 770 nTPM
pancreas: 14 nTPM
epididymis: 13 nTPM
thyroid gland: 12 nTPM
parathyroid gland: 7.3 nTPM
salivary gland: 7.1 nTPM

Single-cell type

cytotrophoblasts: 49 nCPM
gastric chief cells: 42 nCPM
migrating cytotrophoblasts: 39 nCPM
syncytiotrophoblasts: 35 nCPM
gastric progenitor cells: 33 nCPM
extravillous trophoblasts: 31 nCPM

Immune cell

memory B-cell: 2.1 nTPM
memory CD4 T-cell: 0.9 nTPM
gdT-cell: 0.7 nTPM
MAIT T-cell: 0.7 nTPM
memory CD8 T-cell: 0.4 nTPM
naive B-cell: 0.2 nTPM

Brain region

cerebral cortex: 0.8 nTPM
cerebellum: 0.3 nTPM
pons: 0.3 nTPM
basal ganglia: 0.2 nTPM
thalamus: 0.2 nTPM
white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRSS16 as an antibody target. Whether an autoantibody or antibody against PRSS16 could matter depends on whether native PRSS16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRSS16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRSS16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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