PRSS1

Protein identityUniProt · HPA

UniProt accession

P07477

Gene

PRSS1

Ensembl

ENSG00000204983

Chromosome

7

Canonical length

247 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Endoplasmic reticulum,Vesicles

Secretome location

Secreted to digestive system

OverviewNCBI Gene

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>P07477|PRSS1
     1  MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS
    61  AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN
   121  ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT
   181  SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK
   241  NTIAANS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRSS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

319,717 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRSS1.

Disease | AllUniProt

Conditions PRSS1 is implicated in, by any mechanism.

• Pancreatitis, hereditary (PCTT) MIM:167800

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 901 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hereditary pancreatitis
• PRSS1-related disorder
• Trypsinogen deficiency
• Vitamin D-dependent rickets type II with alopecia
• Myoepithelial tumor

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.86

gnomAD pLI

0

gnomAD missense Z

-2.01

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• digestion
• extracellular matrix disassembly
• proteolysis

Molecular functions

• metal ion binding
• serine-type endopeptidase activity

Cellular components

• blood microparticle
• extracellular matrix
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Serine proteases, trypsin domain
• Peptidase S1A, chymotrypsin family
• Peptidase S1, PA clan
• Serine proteases, trypsin family, histidine active site
• Serine proteases, trypsin family, serine active site
• Serine Proteases (Peptidase S1 Family)
• Trypsin

KeywordsUniProt

• Calcium
• Digestion
• Disulfide bond
• Hydrolase
• Metal-binding
• Protease
• Secreted
• Serine protease
• Signal
• Sulfation
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of PRSS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SERPINA1