Seroatlas · Human Serome Atlas

PRRT4

Proline-rich transmembrane protein 4

Also known as: PRRT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JH25
Gene: PRRT4
Ensembl: ENSG00000224940
Chromosome: 7
Canonical length: 899 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Peroxisomes,Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

899 residues, UniProt reviewed canonical sequence.

>C9JH25|PRRT4
     1  MARHGCLGLG LFCCVLFAAT VGPQPTPSIP GAPATTLTPV PQSEASMLSL NLGLNFKFHL
    61  RGPAAVWGSP VTETQPLSLG PGQEPGEEVA SGLRTDPLWE LLVGSSGNSL TEWGSTEGGS
   121  KPRASSLLPE STSRRSGPSD GPTAPYQPRR STVTWDTALM VTALPSSAPR PHQSELELKF
   181  DMALRAGAAP TLGHRTLPLL PSLRASLAEI AGRLGPFGFF GTTLSPLRNF SGLSPPGETT
   241  STSSASGVSG SLGFLGTTLS LPPYSLERKL SSPSPLDPAA SLSFASIATT SLDPTVPISG
   301  PDDLSPPASL GNPSGQPECG PGSCSVGELP EREGQPPEAP RPLFFLTLEA DWAEARARWG
   361  LAWEAHVYGV GALFGLVALL ALLALALLPW RCPPGAPCLA LLDLLLLSAG TTRAFPLFYD
   421  AYGHRDRLPA LAWLLLQDLP LPCLAAGLGL ACLLLARPRP PRCPTGLAAL LLLGLGLAAA
   481  AALGSAAHRP LRPLRLASRG LHAFLAAFLS GLLLALSCWG GRRRRAGAPL GGSGFKGATP
   541  LPQGRSPFAP RESWRRAART APVAGTFGLL SGALQGYEVL HALGYGGQSG LEGPWPWWAF
   601  QLGLRLGEVG VALPLALLGL YPALCSPRVP PRCWAKLFRL SPGHAAPLLP GGWVTGPPDK
   661  EPLGSAIARG DAELLQLCAL AGPGPDLLLQ GGGCRGFEGA AANPAPSPAS SPCSDYTVDF
   721  RPPSPINLRR SIEEALCSEA LLAPGLFQGP AFEDALPGLG LYRTASLGTG GRASERSGEA
   781  SGPAAPPELP SPGAWPAGSS VSSGSFCGLS RDSSSMLLCS SPDRPPRCPL VCVLSPPRPS
   841  GSSPSLPASG SYQALSPPSR DSPEPASELQ AEEALLQEQF LDACRQIDEL SVGSDTIDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 55 nTPM
adipose tissue: 16 nTPM
breast: 8.6 nTPM
cerebellum: 7.2 nTPM
hypothalamus: 7 nTPM
basal ganglia: 5.3 nTPM

Single-cell type

retinal amacrine cells: 31 nCPM
neutrophil progenitors: 22 nCPM
adrenal medulla cells: 21 nCPM
adipocytes: 21 nCPM
retinal horizontal cells: 10 nCPM
brain inhibitory neurons: 9.4 nCPM

Immune cell

naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 12 nTPM
medulla oblongata: 9.2 nTPM
midbrain: 9.2 nTPM
pons: 7.5 nTPM
spinal cord: 6.7 nTPM
thalamus: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Proline-rich transmembrane protein 3/4
Proline-rich transmembrane protein 3 domain
Proline-rich transmembrane domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRT4 as an antibody target. Whether an autoantibody or antibody against PRRT4 could matter depends on whether native PRRT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...