Seroatlas · Human Serome Atlas

PRRT3

Proline-rich transmembrane protein 3

Also known as: FLJ33674, PRRT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5FWE3
Gene: PRRT3
Ensembl: ENSG00000163704
Chromosome: 3
Canonical length: 981 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

981 residues, UniProt reviewed canonical sequence.

>Q5FWE3|PRRT3
     1  MASSPWGCVC GLLLLLLPLL GTGPALGRGF PRPLENSEIP MIPGAHPKGS VGSEPQAFDV
    61  FPENPRADSH RNSDVRHAPA EEMPEKPVAS PLGPALYGPK AAQGAQRERL PVTDDLQMAQ
   121  GPSSHGWTGP LDSQELLQQE AVAPHPVGHP HLTFIPTTPR RQLRVATVPP SLQHEGQEGQ
   181  WPPRDEGLKA KTKSRVPPTS PSDHQGPPHT LVSHSGTVKR PVLEGQGGFE EHLQEAAQGP
   241  HFTQQDPAAP DVGSVPPVEV VYSQEPGAQP DLALARSLPP AEELPVETPK RAGAEVSWEV
   301  SSPGPPPKQA DLPDAKDSPG PQPTDPPASE APDRPSKPER AAMNGADPIS PQRVRGAVEA
   361  PGTPKSLIPG PSDPGPAVNR TESPMGALQP DEAEEWPGRP QSHPPAPPVQ APSTSRRGLI
   421  RVTTQRALGQ PPPPEPTASS MASAPASSPP ANATAPPLRW GPLRRVLSFS WELHVYGVGV
   481  LFLLPALLAL AALAAAPAGP RLALVAAVLV LVASALRSAY MLTDPYGSQA RLGVRGGLVL
   541  YNLPFPLLLT ALAALTLLGL GAGLPPPLQN PLLLGAVALV HGVGLLATDL LSTWSVLNLL
   601  TQGLSCAWGA AVALGTLCLC RRRLLDGPRG WDASPGPRLL AVAGALGLLA SGLQLAAALW
   661  LYPGPGRVGR FSWAWWGVHF WLRLLELTWA LALALAAVAA ARPRPPTEHA CWAKLMRLAC
   721  PAPSGKSEVP ERPNNCYAGP SNVGAGSLDI SKSLIRNPAE SGQLATPSSG AWGSAASLGR
   781  GPQGGPGLSR NGVGPAPSLS ELDLRPPSPI NLSRSIDAAL FREHLVRDSV FQRCGLRGLA
   841  SPPPGGALRP RRGSHPKAEL DDAGSSLLRG RCRSLSDVRV RGPVPQHVVE APDGAAAAAS
   901  GSSLDSFSRG SLKISWNPWR HGLSSVDSLP LDELPSTVQL LPAPTPAPDS TAARQGDGQG
   961  EVQPRGKPGE SRSASSDTIE L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 14 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 13 nTPM
cerebellum: 12 nTPM
pituitary gland: 10 nTPM
hippocampal formation: 7.4 nTPM

Single-cell type

cardiomyocytes: 43 nCPM
respiratory ciliated cells: 40 nCPM
epicardial cells: 34 nCPM
fallopian tube ciliated cells: 29 nCPM
corticotrophs: 29 nCPM
platelets: 24 nCPM

Immune cell

MAIT T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM
memory CD4 T-cell: 1.1 nTPM
memory CD8 T-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM
naive CD8 T-cell: 1 nTPM

Brain region

cerebral cortex: 48 nTPM
cerebellum: 44 nTPM
pons: 35 nTPM
basal ganglia: 34 nTPM
white matter: 33 nTPM
amygdala: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.35
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Proline-rich transmembrane protein 3/4
Proline-rich transmembrane protein 3 domain
Proline-rich transmembrane protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRT3 as an antibody target. Whether an autoantibody or antibody against PRRT3 could matter depends on whether native PRRT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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