Seroatlas · Human Serome Atlas

PRRC2C

Protein PRRC2C

Also known as: BAT2D1, BAT2L2, KIAA1096, PRC2C_HUMAN, XTP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y520
Gene: PRRC2C
Ensembl: ENSG00000117523
Chromosome: 1
Canonical length: 2896 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in stress granule assembly. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2896 residues, UniProt reviewed canonical sequence.

>Q9Y520|PRRC2C
     1  MSEKSGQSTK AKDGKKYATL SLFNTYKGKS LETQKTTARH GLQSLGKVGI SRRMPPPANL
    61  PSLKAENKGN DPNVNIVPKD GTGWASKQEQ HEEEKTPEVP PAQPKPGVAA PPEVAPAPKS
   121  WASNKQGGQG DGIQVNSQFQ QEFPSLQAAG DQEKKEKETN DDNYGPGPSL RPPNVACWRD
   181  GGKAAGSPSS SDQDEKLPGQ DESTAGTSEQ NDILKVVEKR IACGPPQAKL NGQQAALASQ
   241  YRAMMPPYMF QQYPRMTYPP LHGPMRFPPS LSETNKGLRG RGPPPSWASE PERPSILSAS
   301  ELKELDKFDN LDAEADEGWA GAQMEVDYTE QLNFSDDDEQ GSNSPKENNS EDQGSKASEN
   361  NENKKETDEV SNTKSSSQIP AQPSVAKVPY GKGPSFNQER GTSSHLPPPP KLLAQQHPPP
   421  DRQAVPGRPG PFPSKQQVAD EDEIWKQRRR QQSEISAAVE RARKRREEEE RRMEEQRKAA
   481  CAEKLKRLDE KLGILEKQPS PEEIRERERE KEREREKELE KEQEQEREKE REKDRERQQE
   541  KEKELEKEQE KQREMEKERK QEKEKELERQ KEKEKELQKM KEQEKECELE KEREKLEEKI
   601  EPREPNLEPM VEKQESENSC NKEEEPVFTR QDSNRSEKEA TPVVHETEPE SGSQPRPAVL
   661  SGYFKQFQKS LPPRFQRQQE QMKQQQWQQQ QQQGVLPQTV PSQPSSSTVP PPPHRPLYQP
   721  MQPHPQHLAS MGFDPRWLMM QSYMDPRMMS GRPAMDIPPI HPGMIPPKPL MRRDQMEGSP
   781  NSSESFEHIA RSARDHAISL SEPRMLWGSD PYPHAEPQQA TTPKATEEPE DVRSEAALDQ
   841  EQITAAYSVE HNQLEAHPKA DFIRESSEAQ VQKFLSRSVE DVRPHHTDAN NQSACFEAPD
   901  QKTLSAPQEE RISAVESQPS RKRSVSHGSN HTQKPDEQRS EPSAGIPKVT SRCIDSKEPI
   961  ERPEEKPKKE GFIRSSEGPK PEKVYKSKSE TRWGPRPSSN RREEVNDRPV RRSGPIKKPV
  1021  LRDMKEEREQ RKEKEGEKAE KVTEKVVVKP EKTEKKDLPP PPPPPQPPAP IQPQSVPPPI
  1081  QPEAEKFPST ETATLAQKPS QDTEKPLEPV STVQVEPAVK TVNQQTMAAP VVKEEKQPEK
  1141  VISKDLVIER PRPDSRPAVK KESTLPPRTY WKEARERDWF PDQGYRGRGR GEYYSRGRSY
  1201  RGSYGGRGRG GRGHTRDYPQ YRDNKPRAEH IPSGPLRQRE ESETRSESSD FEVVPKRRRQ
  1261  RGSETDTDSE IHESASDKDS LSKGKLPKRE ERPENKKPVK PHSSFKPDNH VRIDNRLLEK
  1321  PYVRDDDKAK PGFLPKGEPT RRGRGGTFRR GGRDPGGRPS RPSTLRRPAY RDNQWNPRQS
  1381  EVPKPEDGEP PRRHEQFIPI AADKRPPKFE RKFDPARERP RRQRPTRPPR QDKPPRFRRL
  1441  REREAASKSN EVVAVPTNGT VNNVAQEPVN TLGDISGNKT PDLSNQNSSD QANEEWETAS
  1501  ESSDFNERRE RDEKKNADLN AQTVVKVGEN VLPPKREIAK RSFSSQRPVD RQNRRGNNGP
  1561  PKSGRNFSGP RNERRSGPPS KSGKRGPFDD QPAGTTGVDL INGSSAHHQE GVPNGTGQKN
  1621  SKDSTGKKRE DPKPGPKKPK EKVDALSQFD LNNYASVVII DDHPEVTVIE DPQSNLNDDG
  1681  FTEVVSKKQQ KRLQDEERRK KEEQVIQVWN KKNANEKGRS QTSKLPPRFA KKQATGIQQA
  1741  QSSASVPPLA SAPLPPSTSA SVPASTSAPL PATLTPVPAS TSAPVPASTL APVLASTSAP
  1801  VPASPLAPVS ASASVSASVP ASTSAAAITS SSAPASAPAP TPILASVSTP ASVTILASAS
  1861  IPILASALAS TSAPTPAPAA SSPAAPVITA PTIPASAPTA SVPLAPASAS APAPAPTPVS
  1921  APNPAPPAPA QTQAQTHKPV QNPLQTTSQS SKQPPPSIRL PSAQTPNGTD YVASGKSIQT
  1981  PQSHGTLTAE LWDNKVAPPA VLNDISKKLG PISPPQPPSV SAWNKPLTSF GSAPSSEGAK
  2041  NGQESGLEIG TDTIQFGAPA SNGNENEVVP VLSEKSADKI PEPKEQRQKQ PRAGPIKAQK
  2101  LPDLSPVENK EHKPGPIGKE RSLKNRKVKD AQQVEPEGQE KPSPATVRST DPVTTKETKA
  2161  VSEMSTEIGT MISVSSAEYG TNAKESVTDY TTPSSSLPNT VATNNTKMED TLVNNVPLPN
  2221  TLPLPKRETI QQSSSLTSVP PTTFSLTFKM ESARKAWENS PNVREKGSPV TSTAPPIATG
  2281  VSSSASGPST ANYNSFSSAS MPQIPVASVT PTASLSGAGT YTTSSLSTKS TTTSDPPNIC
  2341  KVKPQQLQTS SLPSASHFSQ LSCMPSLIAQ QQQNPQVYVS QSAAAQIPAF YMDTSHLFNT
  2401  QHARLAPPSL AQQQGFQPGL SQPTSVQQIP IPIYAPLQGQ HQAQLSLGAG PAVSQAQELF
  2461  SSSLQPYRSQ PAFMQSSLSQ PSVVLSGTAI HNFPTVQHQE LAKAQSGLAF QQTSNTQPIP
  2521  ILYEHQLGQA SGLGGSQLID THLLQARANL TQASNLYSGQ VQQPGQTNFY NTAQSPSALQ
  2581  QVTVPLPASQ LSLPNFGSTG QPLIALPQTL QPPLQHTTPQ AQAQSLSRPA QVSQPFRGLI
  2641  PAGTQHSMIA TTGKMSEMEL KAFGSGIDIK PGTPPIAGRS TTPTSSPFRA TSTSPNSQSS
  2701  KMNSIVYQKQ FQSAPATVRM TQPFPTQFAP QILSQPNLVP PLVRAPHTNT FPAPVQRPPM
  2761  ALASQMPPPL TTGLMSHARL PHVARGPCGS LSGVRGNQAQ AALKAEQDMK AKQRAEVLQS
  2821  TQRFFSEQQQ SKQIGGGKAQ KVDSDSSKPP ETLTDPPGVC QEKVEEKPPP APSIATKPVR
  2881  TGPIKPQAIK TEETKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRC2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 66 nTPM
thymus: 45 nTPM
skin: 42 nTPM
esophagus: 42 nTPM
lymph node: 41 nTPM
spleen: 41 nTPM

Single-cell type

neutrophils: 721 nCPM
syncytiotrophoblasts: 712 nCPM
endometrial glandular cells: 481 nCPM
ocular epithelial cells: 477 nCPM
urothelial cells: 462 nCPM
endometrial luminal cells: 439 nCPM

Immune cell

neutrophil: 2.5 nTPM
basophil: 2.1 nTPM
NK-cell: 2 nTPM
naive B-cell: 1.5 nTPM
plasmacytoid DC: 1.2 nTPM
gdT-cell: 1.1 nTPM

Brain region

hypothalamus: 87 nTPM
cerebral cortex: 86 nTPM
cerebellum: 79 nTPM
white matter: 78 nTPM
medulla oblongata: 78 nTPM
pons: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 2.49
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRC2C as an antibody target. Whether an autoantibody or antibody against PRRC2C could matter depends on whether native PRRC2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRC2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRC2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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