Seroatlas · Human Serome Atlas

PRRC2B

Protein PRRC2B

Also known as: BAT2L, BAT2L1, KIAA0515, LQFBS-1, MGC10526, PRC2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JSZ5
Gene: PRRC2B
Ensembl: ENSG00000288701
Chromosome: 9
Canonical length: 2229 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2229 residues, UniProt reviewed canonical sequence.

>Q5JSZ5|PRRC2B
     1  MSDRLGQITK GKDGKSKYST LSLFDKYKGK SVDAIRSSVI PRHGLQSLGK VAAARRMPPP
    61  ANLPSLKSEN KGNDPNIVIV PKDGTGWANK QDQQDPKSSS ATASQPPESL PQPGLQKSVS
   121  NLQKPTQSIS QENTNSVPGG PKSWAQLNGK PVGHEGGLRG SSRLLSFSPE EFPTLKAAGG
   181  QDKAGKEKGV LDLSYGPGPS LRPQNVTSWR EGGGRHIISA TSLSTSPTEL GSRNSSTGDG
   241  APSSACTSDS KDPSLRPAQP VRKGASQFMG NVYHPPTYHD MLPAFMCSPK SSENQGTVER
   301  GSFPLPQLRL EPRVPFRQFQ MNDQDGKENR LGLSRPLRPL RQLVERAPRP TIINAENLKG
   361  LDDLDADADD GWAGLHEEVD YSEKLKFSDD EEEEEVVKDG RPKWNSWDPR RQRQLSMSSA
   421  DSADAKRTRE EGKDWAEAVG ASRVVRKAPD PQPPPRKLHG WAPGPDYQKS SMGSMFRQQS
   481  IEDKEDKPPP RQKFIQSEMS EAVERARKRR EEEERRAREE RLAACAAKLK QLDQKCKQAR
   541  KAGEARKQAE KEVPWSPSAE KASPQENGPA VHKGSPEFPA QETPTTFPEE APTVSPAVAQ
   601  SNSSEEEARE AGSPAQEFKY QKSLPPRFQR QQQQQQQEQL YKMQHWQPVY PPPSHPQRTF
   661  YPHHPQMLGF DPRWMMMPSY MDPRITPTRT PVDFYPSALH PSGLMKPMMP QESLNGTGCR
   721  SEDQNCVPPL QERKVTPIDS PPVWSPEGYM ALQSKGYPLP HPKSSDTLAM DMRVRNESSF
   781  SASLGRAGGV SAQRDLFEER GEEYLSAFDK KAQADFDSCI SSQRIGQELL FPPQENVQDA
   841  GAPGGHTQNL RCSPLEPDFV PDEKKPECGS WDVSHQPETA DTAHGVERET PREGTAFNIS
   901  SWDKNGSPNK QPSSEPEWTP EPRSSSSQHP EQTGRTRRSG PIKKPVLKAL KVEDKEKELE
   961  KIKQELGEES TRLAKEKEQS PTAEKDEDEE NDASLANSST TTLEDKGPGH ATFGREATKF
  1021  EEEEKPDKAW EARPPRESSD VPPMKRNNWI FIDEEQAFGV RGQARGRGRG FREFTFRGRP
  1081  AGGNGSGLCG GGVLGARSIY CSSQRSGRGR GLREFARPED CPRAKPRRRV ASETHSEGSE
  1141  YEELPKRRRQ RGSENGNEGS LLEREESTLK KGDCRDSWRS NKGCSEDHSG LDAKSRGPRA
  1201  FGRALPPRLS NCGYGRRTFV SKESPHWQSK SPGSSWQEYG PSDTCGSRRP TDRDYVPDSY
  1261  RHPDAFGGRG FEDSRAEDKR SFFQDEHVAD SENAENRPFR RRRPPRQDKP PRFRRLRQER
  1321  ESLGLWGPEE EPHLLAGQWP GRPKLCSGDK SGTVGRRSPE LSYQNSSDHA NEEWETASES
  1381  SDFSERRERR EGPGSEPDSQ VDGGLSGASL GEKKELAKRS FSSQRPVVDR QSRKLEPGGF
  1441  GEKPVRPGGG DTSPRYESQQ NGTPLKVKRS PDEALPGGLS GCSSGSGHSP YALERAAHAS
  1501  ADLPEASSKK AEKEAKLAAP RAGEQGEAMK QFDLNYGSAI IENCGSSPGE ESEVGSMVGE
  1561  GFIEVLTKKQ RRLLEEERRK KEQAVQVPVK GRGLSSRIPP RFAKKQNNLC LEQGDVTVPG
  1621  SSLGTEIWES SSQALPVQAP ANDSWRKAVT AFSSTETGSA EQGFKSSQGD SGVDLSAESR
  1681  ESSATSSQRS SPYGTLKPEE MSGPGLAEPK ADSHKEQAPK PSEQKDSEQG SGQSKEHRPG
  1741  PIGNERSLKN RKGSEGAERL QGAVVPPVNG VEIHVDSVLP VPPIEFGVSP KDSDFSLPPG
  1801  SASGPTGSPV VKLQDALASN AGLTQSIPIL RRDHHIQRAI GLSPMSFPTA DLTLKMESAR
  1861  KAWENSPSLP EQSSPGGAGS GIQPPSSVGA SSGVNYSSFG GVSMPPMPVA SVAPSASMPG
  1921  SHLPPLYLDG HVFASQPRLV PQTIPQQQSY QQAAAAQQIP ISLHTSLQAQ AQLGLRGGLP
  1981  VSQSQEIFSS LQPFRSQVYM HPSLSPPSTM ILSGGTALKP PYSAFPGMQP LEMVKPQSGS
  2041  PYQPMSGNQA LVYEGQLSQA AGLGASQMLD SQLPQLTMPL PRYGSGQQPL ILPQSIQLPP
  2101  GQSLSVGAPR RIPPPGSQPP VLNTSREPSQ MEMKGFHFAD SKQNVPSGGP VPSPQTYRPS
  2161  SASPSGKPSG SAVNMGSVQG HYVQQAKQRV DEKPSLGAVK LQEAPSAASQ MKRTGAIKPR
  2221  AVKVEESKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRRC2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 67 nTPM
skin: 58 nTPM
ovary: 50 nTPM
skeletal muscle: 42 nTPM
lymph node: 41 nTPM
pancreas: 39 nTPM

Single-cell type

salivary myoepithelial cells: 223 nCPM
salivary ionocytes: 197 nCPM
sertoli cells: 191 nCPM
corticotrophs: 187 nCPM
pancreatic acinar cells: 173 nCPM
thyrotrophs: 173 nCPM

Immune cell

naive B-cell: 4.7 nTPM
basophil: 3.9 nTPM
plasmacytoid DC: 3.9 nTPM
NK-cell: 3.7 nTPM
gdT-cell: 3.6 nTPM
memory CD8 T-cell: 3.6 nTPM

Brain region

cerebral cortex: 297 nTPM
hippocampal formation: 275 nTPM
amygdala: 253 nTPM
basal ganglia: 238 nTPM
white matter: 228 nTPM
hypothalamus: 220 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 0.71
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell differentiation

Molecular functions

RNA binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRRC2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EHMT2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRRC2B as an antibody target. Whether an autoantibody or antibody against PRRC2B could matter depends on whether native PRRC2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRRC2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRRC2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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