Seroatlas · Human Serome Atlas

PRR9

Proline-rich protein 9

Also known as: PRR9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T870
Gene
PRR9
Ensembl
ENSG00000203783
Chromosome
1
Canonical length
116 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for PRR9 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>Q5T870|PRR9
     1  MSFSEQQCKQ PCVPPPCLPK TQEQCQAKAE EVCLPTCQHP CQDKCLVQAQ EVCLSQCQES
    61  SQEKCPQQGQ EPYLPPCQDQ CPPQCAEPCQ ELFQTKCVEV CPQKVQEKCS SPGKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • skin: 54 nTPM
  • testis: 2.7 nTPM
  • adipose tissue: 0.9 nTPM
  • thymus: 0.6 nTPM
  • bone marrow: 0.4 nTPM
  • breast: 0.3 nTPM

Single-cell type

  • syncytiotrophoblasts: 24 nCPM
  • late spermatids: 18 nCPM
  • early spermatids: 4.2 nCPM
  • epicardial cells: 2.3 nCPM
  • suprabasal keratinocytes: 1.1 nCPM
  • mesothelial cells: 0.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 1.1 nTPM
  • medulla oblongata: 1 nTPM
  • midbrain: 1 nTPM
  • choroid plexus: 0.9 nTPM
  • white matter: 0.8 nTPM
  • cerebral cortex: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
0.01
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

  • Proline-rich region-containing protein 9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR9 as an antibody target. Whether an autoantibody or antibody against PRR9 could matter depends on whether native PRR9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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