PRR4
Proline-rich protein 4
Also known as: LPRP, PROL4, PROL4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q16378
- Gene
- PRR4
- Ensembl
- ENSG00000111215
- Chromosome
- 12
- Canonical length
- 134 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
134 residues, UniProt reviewed canonical sequence.
>Q16378|PRR4
1 MLLVLLSVVL LALSSAQSTD NDVNYEDFTF TIPDVEDSSQ RPDQGPQRPP PEGLLPRPPG
61 DSGNQDDGPQ QRPPKPGGHH RHPPPPPFQN QQRPPRRGHR QLSLPRFPSV SLQEASSFFQ
121 RDRPARHPQE QPLWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 6,405 nTPM
Expression across tissuesHPA
Tissue
- salivary gland: 6,405 nTPM
- esophagus: 135 nTPM
- skin: 75 nTPM
- lung: 70 nTPM
- stomach: 62 nTPM
- breast: 9 nTPM
Single-cell type
- lacrimal acinar cells: 1,970 nCPM
- salivary acinar cells: 408 nCPM
- submucosal glandular cells: 327 nCPM
- salivary myoepithelial cells: 129 nCPM
- mucous neck cells: 39 nCPM
- neutrophils: 27 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.5 nTPM
- cerebral cortex: 0.3 nTPM
- amygdala: 0.1 nTPM
- pons: 0.1 nTPM
- thalamus: 0.1 nTPM
- basal ganglia: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.04
- gnomAD missense Z
- -0.14
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRR4 as an antibody target. Whether an autoantibody or antibody against PRR4 could matter depends on whether native PRR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRR4 is annotated as secreted, so native PRR4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PRR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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