Seroatlas · Human Serome Atlas

PRR36

Proline-rich protein 36

Also known as: PRR36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H6K5
Gene
PRR36
Ensembl
ENSG00000183248
Chromosome
19
Canonical length
1346 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear speckles,Golgi apparatus

OverviewNCBI Gene

This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. [provided by RefSeq, Oct 2013]

Canonical amino-acid sequenceUniProt

1346 residues, UniProt reviewed canonical sequence.

>Q9H6K5|PRR36
     1  MDNKRDKAKA GAAARTPAAR APGLLTPRPP GSPRPPPPVT PAALRVLGAA GAVGRKPLAE
    61  RAGGIGGATI PESAPRAGPT RSAGTSSRNP ASRPPASGRG ERAPPAKNTS PGPVSSPGRA
   121  SGTTRPGPLG QKGLRISAEE TVARGKATEA PKRSALSAGA RRDTSGPTPG TPSPAMARRS
   181  RAAGTEVGLP RPAPSARPRP PTEGPRKSVS SASEHSTTEP SPAARRRPSA GGGLQRPASR
   241  SLSSSATPLS SPARSGPSAR GTPRAPAHPS QPKPKGLQAL RPPQVTPPRK DAAPALGPLS
   301  SSPLATPSPS GTKARPVPPP DNAATPLPAT LPPSPPVTPP PPAALQSQAP PTLPATPHSS
   361  SLTCQLATPL PLAPPSPSAP PSLQTLPSPP ATPPSQVPPT QLIMSFPEAG VSSLATAAFV
   421  ASVSPSVSSP LQSMPPTQAN PALPSLPTLL SPLATPPLSA MSPLQGPVSP ATSLGNSAFP
   481  LAALPQPGLS ALTTPPPQAS PSPSPPSLQA TPHTLATLPL QDSPLLATLP LQASPSPLTT
   541  VSLQDPPLVS PSLLASPPLQ APPHPQAPPS MTTPPMQAPP SLQTIPPIQV PHSLTSPSLQ
   601  APPSPLALSS LQATTSLGSP TLQATHSFLT MSPRQTQASL ISPSRPASTP PDSPPLQAPL
   661  SLPASPPLQT SLSPAVSPLS SPLTIHPLQA LSSLASHSPQ APLSSLIMPP LETQSSLAPP
   721  SLQTPPASLT TPPLENLPSL APPPLQTASA PLTTPPLENL PSLAPPPLQT ASAPLTTPHL
   781  ETPPCPAPCP LQAPPSPLTT PPPETPSSIA TPPPQAPPAL ASPPLQGLPS PPLSPLATPP
   841  PQAPPALALP PLQAPPSPPA SPPLSPLATP SPQAPNALAV HLLQAPFSPP PSPPVQAPFS
   901  PPASPPVSPS ATPPSQAPPS LAAPPLQVPP SPPASPPMSP SATPPPQAPP PLAAPPLQVP
   961  PSPPASPPMS PSATPPPRVP PLLAAPPLQV PPSPPASLPM SPLAKPPPQA PPALATPPLQ
  1021  ALPSPPASFP GQAPFSPSAS LPMSPLATPP PQAPPVLAAP LLQVPPSPPA SPTLQAPRRP
  1081  PTPGPDTSVS GPRLTLALAP GPPPPPSRSP SSTLSGPDLA GHSSSATSTP EELRGYDSGP
  1141  EGGAAASPPP DAELAACHPA AWSRGPAPPL AFRGAPGAPL PWPPATGPGS ADGLCTIYET
  1201  EGPESATPAP GALDPGPSPG TSGGKAAAGA GAGASSRSPK QARLGELPLG ALQASVVQHL
  1261  LSRTLLLAAA EGAAGGSGGG PGGAEGGGVT GGARAALSDA ELGRWAELLS PLDESRASIT
  1321  SVTSFSPDDV ASPQGDWTVV EVETFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 46 nTPM
  • cerebral cortex: 34 nTPM
  • pituitary gland: 28 nTPM
  • amygdala: 17 nTPM
  • basal ganglia: 17 nTPM
  • hypothalamus: 15 nTPM

Single-cell type

  • gonadotrophs: 22 nCPM
  • oocytes: 18 nCPM
  • other brain neurons: 15 nCPM
  • brain excitatory neurons: 14 nCPM
  • lactotrophs: 12 nCPM
  • brain inhibitory neurons: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 96 nTPM
  • basal ganglia: 68 nTPM
  • cerebellum: 67 nTPM
  • amygdala: 64 nTPM
  • white matter: 58 nTPM
  • hypothalamus: 52 nTPM

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRR36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR36 as an antibody target. Whether an autoantibody or antibody against PRR36 could matter depends on whether native PRR36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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