Seroatlas · Human Serome Atlas

PRR35

Proline-rich protein 35

Also known as: C16orf11, PRR35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG20
Gene: PRR35
Ensembl: ENSG00000161992
Chromosome: 16
Canonical length: 571 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

No narrative summary is available for PRR35 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

571 residues, UniProt reviewed canonical sequence.

>P0CG20|PRR35
     1  MSREAGSCRV GTGARARSRK PKKPHYIPRP WGKPYNYKCF QCPFTCLEKS HLYNHMKYSL
    61  CKDSLSLLLD SPDWACRRGS TTPRPHAPTP DRPGESDPGR QPQGARPTGA APAPDLVVAD
   121  IHSLHCGGGP KSRAKGSPGP PPPVARATRK GPGPSGLLPE SWKPGMGGDP RGVGAGDMAS
   181  AGPEGSVPCY PPPAPGEFPE AHSLHLSLLG VNYPLSPGLF SYLGPSLAAA AHVPFLASAS
   241  PLLPPATAFP AVQPPQRPTP APRLYYPLLL EHTLGLPAGK AALAKAPVSP RSPSGTPAPG
   301  LLKVPVPGLG PWPRVTPRDP GQEGELERAA QSDPRRRLSL GSRLELPKAS PSLTRFCSRS
   361  SLPTGSSVML WPEDGDPGGP ETPGPEGPLP LQPRGPVPGS PEHVGEDLTR ALGDYARVEQ
   421  RLGQLGPAGG LAPRPLREQL GKIRLELLTI HQALEQAVRP PDAPLDLSVK RAPAKGPQAL
   481  GEAWGRPELG PVLTGGTPEP PGMLGPAAPQ PFSGHTTKCE ADSSVPPPGL PLAAPDDPVI
   541  PGSGWGTCVA TRSSQTPEAV CGLQSPQGAE V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 137 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 137 nTPM
kidney: 16 nTPM
spinal cord: 2.3 nTPM
testis: 1.6 nTPM
pancreas: 1 nTPM
basal ganglia: 0.3 nTPM

Single-cell type

renal connecting tubule cells: 21 nCPM
brain excitatory neurons: 18 nCPM
retinal amacrine cells: 18 nCPM
renal collecting duct principal cells: 16 nCPM
undifferentiated spermatogonia: 5.2 nCPM
renal collecting duct intercalated cells: 4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 96 nTPM
pons: 4.6 nTPM
cerebral cortex: 3.8 nTPM
midbrain: 3.3 nTPM
white matter: 2.7 nTPM
thalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.02
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR35 as an antibody target. Whether an autoantibody or antibody against PRR35 could matter depends on whether native PRR35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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