Seroatlas · Human Serome Atlas

PRR34

Proline-rich protein 34

Also known as: PRR34_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NV39
Gene
PRR34
Canonical length
138 aa

OverviewNCBI Gene

No narrative summary is available for PRR34 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q9NV39|PRR34
     1  MPASATAAWH CPPLCLPPLP ASAPTSPPNP ATRPAPGPGR RARCPQSAHP APTRGALTFW
    61  APGSWPRVLL VPRSPGPVLR APRLPHPAAR ARRRAWHGAR LPGSPARAGR TFQRGLVSNS
   121  WAHAIFLPRP PNVLELQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR34 as an antibody target. Whether an autoantibody or antibody against PRR34 could matter depends on whether native PRR34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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