Seroatlas · Human Serome Atlas

PRR33

Proline-rich protein 33

Also known as: PRR33_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MZF0
Gene
PRR33
Canonical length
331 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRR33 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>A8MZF0|PRR33
     1  MGPQVVASAP EPTRPPSGFV PVSGGGGTHV TQVHIQLAPS PHNGTPEPPR TAPEVGSNSQ
    61  DGDATPSPPR AQPLVPVAHI RPLPTTVQAA SPLPEEPPVP RPPPGFQASV PREASARVVV
   121  PIAPTCRSLE SSPHSLVPMG PGREHLEEPP MAGPAAEAER VSSPAWASSP TPPSGPHPCP
   181  VPKVAPKPRL SGWTWLKKQL LEEAPEPPCP EPRQSLEPEV PTPTEQEVPA PTEQEVPALT
   241  APRAPASRTS RMWDAVLYRM SVAEAQGRLA GPSGGEHTPA SLTRLPFLYR PRFNARKLQE
   301  ATRPPPTVRS ILELSPQPKN FNRTATGWRL Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 33 nTPM
  • spleen: 26 nTPM
  • adrenal gland: 22 nTPM
  • skin: 10 nTPM
  • bone marrow: 9.1 nTPM
  • heart muscle: 7.5 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • neutrophil: 1.4 nTPM
  • naive B-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • white matter: 1.3 nTPM
  • medulla oblongata: 0.7 nTPM
  • thalamus: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM
  • pons: 0.6 nTPM
  • spinal cord: 0.5 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4643
  • Domain of unknown function (DUF4643)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR33 as an antibody target. Whether an autoantibody or antibody against PRR33 could matter depends on whether native PRR33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR33. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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