PRR32
Proline-rich protein 32
Also known as: CXorf64, PRR32_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B1ATL7
- Gene
- PRR32
- Ensembl
- ENSG00000183631
- Chromosome
- X
- Canonical length
- 298 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Plasma membrane,Centrosome
OverviewNCBI Gene
No narrative summary is available for PRR32 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
298 residues, UniProt reviewed canonical sequence.
>B1ATL7|PRR32
1 MACIENVLGG HAPSPLVVSV DKNGNQELHH DMPLQCLSSK PEDDAEPWGQ PQVPLRPSVN
61 VLTDLDSKQL EWPSERTGSC IPLHSLRAHR HPYGPPPAVA EESLATAEVN SSDALAGWRQ
121 EGQDAINVSW EVSGGPPALI VGGTKVNNGG TERGSNNARL HVALPQGKGF FPPRGPQVRG
181 PSHIPTLRSG IVMEVPPGNT RIACRGKLAH VSFPLRGPCH PMHNWPRPIP LSSSTPGLPS
241 CSTVHCFIPP RPPIFNPFLT MPLPFAPPPI FGPPLPSYFA HFHSGGMPAP ASPNREHSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRR32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- tongue: 21 nTPM
- heart muscle: 3.8 nTPM
- skeletal muscle: 0.6 nTPM
- fallopian tube: 0.5 nTPM
- liver: 0.2 nTPM
- salivary gland: 0.2 nTPM
Single-cell type
- salivary ionocytes: 0.4 nCPM
- salivary duct cells: 0.3 nCPM
- respiratory ciliated cells: 0.2 nCPM
- salivary basal cells: 0.2 nCPM
- cardiomyocytes: 0.1 nCPM
- ependymal cells: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- spinal cord: 0.6 nTPM
- choroid plexus: 0.4 nTPM
- medulla oblongata: 0.4 nTPM
- white matter: 0.4 nTPM
- cerebellum: 0.2 nTPM
- hypothalamus: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Protein of unknown function DUF4645
- Domain of unknown function (DUF4645)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRR32 as an antibody target. Whether an autoantibody or antibody against PRR32 could matter depends on whether native PRR32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRR32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRR32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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