Seroatlas · Human Serome Atlas

PRR30

Proline-rich protein 30

Also known as: C2orf53, MGC44505, PRR30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53SZ7
Gene: PRR30
Ensembl: ENSG00000186143
Chromosome: 2
Canonical length: 412 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRR30 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q53SZ7|PRR30
     1  MLPQNKDQVL PQTSVLPGRP TWGFSQLVDS SPHNLQPLSP HQGLPPSQPP FSSTQSRRPS
    61  SPPPASPSPG FQFGSCDSNS DFAPHPYSPS LPSSPTFFHQ NYLSLPRPRA SSPSNHWLYP
   121  SPPLTPSFSP SQPQNSSLPH SPCQSPSHPE ELHSSTLTSP GPSPPSHRLH SNRQTWRWHQ
   181  YRDTGSGSPG VVERCVPSEK DPAQFRDPGA LAQALVVQLG HRRIAHDLRL LLLQHLWLGR
   241  TGQAPVVEYP ICLVCLRPRS PSCPLPRYRT GPRLLAFPQL LPCVQGQESG PLRIGIGFGL
   301  RLPQGQARAL HLLPEKRPKE AGPQGKATQA CGHQLPASQP PAAQARADPV PGTPSQTRSF
   361  RSAGLQSPNS PRCFSGPPPR APKQVTTSLK PRPCPGPKRP VSLELILQKS SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 138 nTPM

Expression across tissuesHPA

Tissue

testis: 138 nTPM
prostate: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 1,334 nCPM
early spermatids: 717 nCPM
late primary spermatocytes: 252 nCPM
leydig cells: 2.9 nCPM
early primary spermatocytes: 1.8 nCPM
peritubular myoid cells: 1.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4679
Domain of unknown function (DUF4679)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR30 as an antibody target. Whether an autoantibody or antibody against PRR30 could matter depends on whether native PRR30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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