Seroatlas · Human Serome Atlas

PRR29

Proline-rich protein 29

Also known as: C17orf72, DKFZp761M2312, FLJ11724, PRR29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C7W0
Gene
PRR29
Ensembl
ENSG00000224383
Chromosome
17
Canonical length
189 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

No narrative summary is available for PRR29 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P0C7W0|PRR29
     1  MASGAGGSWG RSPPQSAVPT PWVTFLQPLS WAVPPAPPQP GRVKEDLLEL MMLQNAQMHQ
    61  LLLSRLVAGA LQPRPASPCP QVYLEVPQEE PEEEEEEMDV REKGPLVFHH HYLPYLMPSP
   121  GALLPWPAPF FPTPACQPYL QDVPRIQHCP ASREREVRAV PPPPPPSATG TVGADVPPAS
   181  DYYDAESLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 55 nTPM
  • choroid plexus: 17 nTPM
  • testis: 13 nTPM
  • hippocampal formation: 11 nTPM
  • lung: 10 nTPM
  • pituitary gland: 10 nTPM

Single-cell type

  • fallopian tube ciliated cells: 186 nCPM
  • ependymal cells: 155 nCPM
  • respiratory ciliated cells: 150 nCPM
  • epididymal efferent duct ciliated cells: 121 nCPM
  • endometrial ciliated cells: 71 nCPM
  • late primary spermatocytes: 21 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • naive CD4 T-cell: 0.7 nTPM
  • intermediate monocyte: 0.5 nTPM
  • gdT-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.4 nTPM

Brain region

  • midbrain: 36 nTPM
  • medulla oblongata: 30 nTPM
  • choroid plexus: 28 nTPM
  • spinal cord: 19 nTPM
  • pons: 13 nTPM
  • hippocampal formation: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0.01
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR29 as an antibody target. Whether an autoantibody or antibody against PRR29 could matter depends on whether native PRR29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...