Seroatlas · Human Serome Atlas

PRR27

Proline-rich protein 27

Also known as: C4orf40, PRR27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6MZM9
Gene
PRR27
Ensembl
ENSG00000187533
Chromosome
4
Canonical length
219 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q6MZM9|PRR27
     1  MKLLLWACIV CVAFARKRRF PFIGEDDNDD GHPLHPSLNI PYGIRNLPPP LYYRPVNTVP
    61  SYPGNTYTDT GLPSYPWILT SPGFPYVYHI RGFPLATQLN VPPLPPRGFP FVPPSRFFSA
   121  AAAPAAPPIA AEPAAAAPLT ATPVAAEPAA GAPVAAEPAA EAPVGAEPAA EAPVAAEPAA
   181  EAPVGVEPAA EEPSPAEPAT AKPAAPEPHP SPSLEQANQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
1,040 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 1,040 nTPM
  • pancreas: 1 nTPM
  • testis: 0.5 nTPM
  • heart muscle: 0.2 nTPM
  • bone marrow: 0.1 nTPM
  • esophagus: 0.1 nTPM

Single-cell type

  • salivary acinar cells: 957 nCPM
  • lacrimal acinar cells: 403 nCPM
  • salivary myoepithelial cells: 60 nCPM
  • late primary spermatocytes: 25 nCPM
  • early spermatids: 12 nCPM
  • neutrophils: 7.8 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 1.1 nTPM
  • cerebellum: 0.9 nTPM
  • cerebral cortex: 0.9 nTPM
  • midbrain: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • hippocampal formation: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Proline-rich protein 27

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR27 as an antibody target. Whether an autoantibody or antibody against PRR27 could matter depends on whether native PRR27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR27 is annotated as secreted, so native PRR27 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRR27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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