Seroatlas · Human Serome Atlas

PRR25

Proline-rich protein 25

Also known as: PRR25_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S07
Gene: PRR25
Canonical length: 402 aa

OverviewNCBI Gene

No narrative summary is available for PRR25 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>Q96S07|PRR25
     1  MARTDQKPPC RGGCWGQPGH PNTGGAAAHP TYHPMGHRPR TCILLRGDQT TGGQAPSREI
    61  SLGPWAAGTH FLAISTTPWG RKTPACISEL PTSSGTAQPL ANAVCEVQTV PGPGLRPQGT
   121  PAMRAPSHKG TPPTPNPWGP EQPQNRHKHP KKGVTGGPSP PPPAASRYGQ TPGREPRVQA
   181  PGLGPCGRPA SGRLLSLHLE KGDGKGTRQR IPLTDAAVGG DRTDIPSAIA AGPARTPDRH
   241  GLPIPGSTPT PMVGSGRLGA PVGRSGGGAS ARSSRPSCAN VLLRADASLG TVLSVLWTGQ
   301  LSRGWALLPP GDAGRHLETS VISAGVAAGI WLVEPGEAAQ DPATRRTAPP RRTASPEPPA
   361  PGAPLPACPG RIPGAARFGP RSCPLGSPAV LAVTTGWSHR SV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -1.05

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR25 as an antibody target. Whether an autoantibody or antibody against PRR25 could matter depends on whether native PRR25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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