Seroatlas · Human Serome Atlas

PRR23E

Proline-rich protein 23E

Also known as: C3orf56, FLJ40141, PR23E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N813
Gene
PRR23E
Ensembl
ENSG00000214324
Chromosome
3
Canonical length
242 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

No narrative summary is available for PRR23E in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q8N813|PRR23E
     1  MGTGASEKQA EQKVRRAFEA SEEAHGTLAA STPWVAMGSA YGSCTCLGAQ PVTDLALWPV
    61  IYSCMGFSPQ AYPAFWAYPW VLYGGYLWMG YPPPAALVPS VWLYWRGASS FDPLIGSPYL
   121  AALAPNLFPF PMKFPPTYSL ASPTLGGATS SHCPQVGCWT PASSAPRAAV EGPSRGAPYL
   181  KTCKAPPSEW ASRFGIWAPL PCCSSELRPL PPSPIEDSQL DPGCSRSSSR SPCRARRRLF
   241  EC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR23E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.6 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • undifferentiated spermatogonia: 1.5 nCPM
  • differentiating spermatogonia: 0.6 nCPM
  • early primary spermatocytes: 0.2 nCPM
  • early spermatids: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0
gnomAD pLI
0

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR23E as an antibody target. Whether an autoantibody or antibody against PRR23E could matter depends on whether native PRR23E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR23E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR23E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR23E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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