Seroatlas · Human Serome Atlas

PRR23D2

Proline-rich protein 23D2

Also known as: P23D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMB1
Gene
PRR23D2
Ensembl
ENSG00000255378
Chromosome
8
Canonical length
279 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRR23D2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>P0DMB1|PRR23D2
     1  MYGYRRLRSP RDSQTEPQND NEGETSLATT QMNPPKRRQV EQGPSTGAKK PSISGAPHLN
    61  SYQSLELPQN QQDSGTEELM IVLEQGTEVR LSLEEVILIL APETVLQLTL ENTVLVIVPE
   121  HVLRSEDGLQ SPVQIQYIIP SVDDFSLEFH AQDGDISDMR RENVPFSPAE EGKAAPLYQQ
   181  PLMIPQANHM AGISPSFLVT PLCIPRCRAA FPQCYPLPPT PSPVGRPRPA DSSFSLHGME
   241  LLCTSSLRPM PPSPSPGPQV YHRVHHRPPS RARRCLFRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR23D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2 nTPM
  • basal ganglia: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR23D2 as an antibody target. Whether an autoantibody or antibody against PRR23D2 could matter depends on whether native PRR23D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR23D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR23D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR23D2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...