Seroatlas · Human Serome Atlas

PRR23D1

Proline-rich protein 23D1

Also known as: P23D1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E9PI22
Gene
PRR23D1
Ensembl
ENSG00000255251
Chromosome
8
Canonical length
279 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRR23D1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>E9PI22|PRR23D1
     1  MYGYRRLRSP RDSQTEPQND NEGETSLATT QMNPPKRRQV EQGPSTGAKK PSISGAPHLN
    61  SYQSLELPQN QQDSGTEELM IVLEQGTEVR LSLEEVILIL APETVLQLTL ENTVLVIVPE
   121  HVLRSEDGLQ SPVQIQYIIP SVDDFSLEFH AQDGDISDMR RENVPFSPAE EGKAAPLYQQ
   181  PLMIPQANHM AGISPSFLVT PLCIPRCRAA FPQCYPLPPT PSPVGRPRPA DSSFSLHGME
   241  LLCTSSLRPM PPSPSPGPQV YHRVHHRPPS RARRCLFRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR23D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
176 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 176 nTPM
  • testis: 1.8 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hypothalamus: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • pons: 0.2 nTPM
  • white matter: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0.42
gnomAD missense Z
0.53

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR23D1 as an antibody target. Whether an autoantibody or antibody against PRR23D1 could matter depends on whether native PRR23D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR23D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR23D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR23D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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