Seroatlas · Human Serome Atlas

PRR23C

Proline-rich protein 23C

Also known as: FLJ46210, PR23C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZRP0
Gene
PRR23C
Ensembl
ENSG00000233701
Chromosome
3
Canonical length
262 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Microtubules,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

No narrative summary is available for PRR23C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q6ZRP0|PRR23C
     1  MGSRPCSPSA CLAPWWGQQP GGPGPAKRSR LEEPAGPESR AAPSPEDPAG TPAVDALTSM
    61  VVLDAGCALR VPLEDVDLVL ELAPMSVLRV SLGGHTLIVI PEVLLSSVDE CSGAQGDWSA
   121  GLEVDVFLGA HGEDVVVEQE VCASVPEIAA EEEAYEEDAD SEFPELWMDS AAGSAAGLYP
   181  SARSMFSPYR EGPIRGPCAL APNPSSERRS PRPIFDLEFH LLEPVPSSPL QPLPPSPSPG
   241  PHARPELPER PPCKVRRRLF QE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR23C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
0.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.8 nTPM
  • retina: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 4.5 nCPM
  • differentiating spermatogonia: 3.8 nCPM
  • early spermatids: 3.7 nCPM
  • early primary spermatocytes: 3 nCPM
  • late primary spermatocytes: 0.7 nCPM
  • adipocytes: 0 nCPM

Immune cell

  • basophil: 1 nTPM
  • neutrophil: 0.4 nTPM
  • eosinophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebellum: 1.6 nTPM
  • cerebral cortex: 1.3 nTPM
  • white matter: 1.3 nTPM
  • amygdala: 1.1 nTPM
  • basal ganglia: 1.1 nTPM
  • hippocampal formation: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.55
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR23C as an antibody target. Whether an autoantibody or antibody against PRR23C could matter depends on whether native PRR23C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR23C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR23C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR23C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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