Seroatlas · Human Serome Atlas

PRR22

Proline-rich protein 22

Also known as: MGC24975, PRR22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ63
Gene: PRR22
Ensembl: ENSG00000212123
Chromosome: 19
Canonical length: 422 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for PRR22 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q8IZ63|PRR22
     1  MQHPKPFCAP AAPQEGFSPQ SLEGAEVLGN QPAPTCAEPP PAMGSLNLYH PPDPEKEVFP
    61  APPAGFQMAP CGCFFDPRIY RIEWTTPDLG QSALYKLAAS SGGPAGVPSA PGSYLLEPQP
   121  YLKAPGLPPY PHYQQAPGGP QFLLPYFPPE GPGPEALGFV GDAGPAAFVE LPLPPLEEGP
   181  APLPPPPPKE NKPPPVLITL PAEPTLPPDA YSHLQGHLGH FPGPEPLAFP VKELQGSGAR
   241  PGVPLYPPGL SELKVAEVKE GALLGAGKAK APKTARALAL PDKVLLEDAM KLFDCLPGAS
   301  EPEGTLCEVP GPALPDSSGG NSADDIRSLC LPEELLSFDY SVPEILDTVS NVDYFFNFKA
   361  LDEEQPPHPG PPATNTPAPI LSGKRKASTA KKGKPGRKAR QPAGPASATP PGPREDLGAT
   421  PH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

testis: 48 nTPM
liver: 12 nTPM
kidney: 7 nTPM
prostate: 6.7 nTPM
spleen: 6.3 nTPM
pancreas: 6 nTPM

Single-cell type

early spermatids: 174 nCPM
late primary spermatocytes: 165 nCPM
late spermatids: 114 nCPM
retinal horizontal cells: 10 nCPM
undifferentiated spermatogonia: 8.1 nCPM
early primary spermatocytes: 7.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 4.4 nTPM
cerebral cortex: 4.1 nTPM
medulla oblongata: 4 nTPM
thalamus: 4 nTPM
basal ganglia: 3.9 nTPM
amygdala: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0.01
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Proline-rich protein 22
Proline-rich protein family 22

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR22 as an antibody target. Whether an autoantibody or antibody against PRR22 could matter depends on whether native PRR22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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