Seroatlas · Human Serome Atlas

PRR20G

Proline-rich protein 20G

Also known as: PR20G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DPQ3
Gene
PRR20G
Ensembl
ENSG00000239620
Chromosome
3
Canonical length
210 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRR20G in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>P0DPQ3|PRR20G
     1  MEEPRHSKRP RFLAPNQASG GPPTEPGCSG VDREDPVDPV QPAKPTAYVK PMRREPPARA
    61  QPAPPAGRGQ RGGGSWRAGR GRGSGAGLLR ALGERVGPGM YLVHLNDHGE LGYQGQLEAR
   121  QTPAFSFTEA ALMPGIVQEG PGPHAAQPEV GLQEPPPAPG PVAVARQTML APSPSLSFRP
   181  PGGSSTLCIV QTSNSTIVQS VPVFPAHSAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR20G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early primary spermatocytes: 81 nCPM
  • differentiating spermatogonia: 59 nCPM
  • undifferentiated spermatogonia: 5.8 nCPM
  • gastric progenitor cells: 1.3 nCPM
  • late spermatids: 0.9 nCPM
  • late primary spermatocytes: 0.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR20G as an antibody target. Whether an autoantibody or antibody against PRR20G could matter depends on whether native PRR20G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR20G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR20G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR20G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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