Seroatlas · Human Serome Atlas

PRR20C

Proline-rich protein 20C

Also known as: PR20C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P86479
Gene
PRR20C
Ensembl
ENSG00000229665
Chromosome
13
Canonical length
221 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene is one of five identical loci in a cluster on chromosome 13q21.1. The predicted protein is proline-rich and contains several dopamine D4 receptor signatures and PRINTS domains. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>P86479|PRR20C
     1  MEEPRPSKRL RSMAPNQASG GPPPEPGCCV ADPEGSVEAD GPAQPAQPAK PIAYVKPFRR
    61  QPPARPESPP PAERGRRRGG SRRPGRGRGR RAGPRGDAGQ RQGAEGLMAP DVHIQLDHHG
   121  EPGHQGEPEI TETAAFSLSE TGPPPGTVQE GPGPDVAQPE LGFQEPPAAP GPQAVDWQPV
   181  LTLYPCIGFR ALGDSAVLQV IQTPQGTYVQ GVPVFLTDIA Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR20C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR20C as an antibody target. Whether an autoantibody or antibody against PRR20C could matter depends on whether native PRR20C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR20C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR20C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR20C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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