PRR18
Proline-rich protein 18
Also known as: MGC35308, PRR18_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N4B5
- Gene
- PRR18
- Ensembl
- ENSG00000176381
- Chromosome
- 6
- Canonical length
- 295 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for PRR18 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
295 residues, UniProt reviewed canonical sequence.
>Q8N4B5|PRR18
1 MPFPPMPPPP APAPGAQAAR QLPRRPCAAG DKKKRPPQRP EGLLSSSWPS ATLKRPPARR
61 GPGLDRTQPP APPGVSPQAL PSRARAPATC APPRPAGSGH SPARTTYAAT SAGTGTTAAG
121 TSSGAGPCPD SAARFCLNLT PEAVLVIQKR HLEKQLLARP RRPFPSPSAE PRRLLAPCLP
181 ARAAGPRRGG PASDPDAPPT AGQGRRAPPP GAQLLHGGLQ VPQLSPRPGA LRPMLKVSLL
241 NERHRYDDVE YEEEPEAVDE GLVRKCTEWL RGVESAAAAR GRAGALDSRR HLSTLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRR18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 50 nTPM
- hippocampal formation: 39 nTPM
- midbrain: 39 nTPM
- basal ganglia: 32 nTPM
- amygdala: 26 nTPM
- hypothalamus: 20 nTPM
Single-cell type
- oligodendrocytes: 75 nCPM
- ependymal cells: 18 nCPM
- respiratory ciliated cells: 18 nCPM
- fallopian tube ciliated cells: 15 nCPM
- oocytes: 9.2 nCPM
- astrocytes: 8.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 270 nTPM
- basal ganglia: 202 nTPM
- midbrain: 140 nTPM
- thalamus: 137 nTPM
- cerebral cortex: 136 nTPM
- medulla oblongata: 128 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.52
- gnomAD pLI
- 0.46
- gnomAD missense Z
- 0.89
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Proline-rich protein 18
- Proline-rich protein family 18
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRR18 as an antibody target. Whether an autoantibody or antibody against PRR18 could matter depends on whether native PRR18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRR18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRR18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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