Seroatlas · Human Serome Atlas

PRR15L

Proline-rich protein 15-like protein

Also known as: ATAD4, MGC11242, PR15L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BU68
Gene
PRR15L
Ensembl
ENSG00000167183
Chromosome
17
Canonical length
103 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

No narrative summary is available for PRR15L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>Q9BU68|PRR15L
     1  MTTEIGWWKL TFLRKKKSTP KVLYEIPDTY AQTEGDAEPP RPDAGGPNSD FNTRLEKIVD
    61  KSTKGKHVKV SNSGRFKEKK KVRATLAENP NLFDDHEEGR SSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR15L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
168 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 168 nTPM
  • small intestine: 121 nTPM
  • rectum: 117 nTPM
  • colon: 104 nTPM
  • pancreas: 99 nTPM
  • stomach: 80 nTPM

Single-cell type

  • enterocytes: 243 nCPM
  • colonocytes: 188 nCPM
  • parietal cells: 133 nCPM
  • goblet cells: 120 nCPM
  • enteric stem cells: 106 nCPM
  • enteric transient amplifying cells: 105 nCPM

Immune cell

  • MAIT T-cell: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • hippocampal formation: 2.6 nTPM
  • cerebellum: 1.6 nTPM
  • cerebral cortex: 1.5 nTPM
  • basal ganglia: 1.3 nTPM
  • medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0.51
gnomAD missense Z
-0.11
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR15L as an antibody target. Whether an autoantibody or antibody against PRR15L could matter depends on whether native PRR15L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR15L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR15L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR15L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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