PRR15
Proline-rich protein 15
Also known as: PRR15_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IV56
- Gene
- PRR15
- Ensembl
- ENSG00000176532
- Chromosome
- 7
- Canonical length
- 129 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Cell Junctions
OverviewNCBI Gene
No narrative summary is available for PRR15 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
129 residues, UniProt reviewed canonical sequence.
>Q8IV56|PRR15
1 MADSGDAGSS GPWWKSLTNS RKKSKEAAVG VPPPAQPAPG EPTPPAPPSP DWTSSSRENQ
61 HPNLLGGAGE PPKPDKLYGD KSGSSRRNLK ISRSGRFKEK RKVRATLLPE AGRSPEEAGF
121 PGDPHEDKQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRR15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 76 nTPM
Expression across tissuesHPA
Tissue
- colon: 76 nTPM
- small intestine: 68 nTPM
- duodenum: 68 nTPM
- cervix: 59 nTPM
- rectum: 49 nTPM
- stomach: 47 nTPM
Single-cell type
- colonocytes: 198 nCPM
- respiratory secretory cells: 129 nCPM
- granulosa cells: 115 nCPM
- enterocytes: 113 nCPM
- oocytes: 92 nCPM
- respiratory deuterosomal cells: 90 nCPM
Immune cell
- memory B-cell: 0.2 nTPM
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- hypothalamus: 3.8 nTPM
- thalamus: 2.9 nTPM
- cerebral cortex: 2.7 nTPM
- amygdala: 2.5 nTPM
- spinal cord: 2.5 nTPM
- white matter: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.24
- gnomAD pLI
- 0.54
- gnomAD missense Z
- -0.34
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRR15 as an antibody target. Whether an autoantibody or antibody against PRR15 could matter depends on whether native PRR15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRR15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRR15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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