Seroatlas · Human Serome Atlas

PRR14L

Protein PRR14L

Also known as: C22orf30, MGC50372, PR14L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5THK1
Gene: PRR14L
Ensembl: ENSG00000183530
Chromosome: 22
Canonical length: 2151 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for PRR14L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

2151 residues, UniProt reviewed canonical sequence.

>Q5THK1|PRR14L
     1  MLSSGVETQP VPLDSSMSAV VQELYSELPV SVSRELHADP EPSVIPDVKP GASSSLLSQN
    61  RALPLELQRT HVESCCEETY ETLDHGSEPG RCGLVDSTAG GSVASGILDR AKRSESMEPK
   121  VFRDPGGQAG IIREPSEGAK EDPHQHSTAA EEKTSPSQED LLMQSSKELS HVDLPEDFLR
   181  SKEGNVQITA ETLLKSAEVQ GMKVNGTKTD NNEGHKNGNV SKDLSAGCGE FQEVDKIMTS
   241  DEVSETSTLV TPEPLTFVDP VLTEATPKEK ECEELKSCPW LSLPGNSAIS NVDNGKEELC
   301  KPNLVCEADD NHQQLHGHHN EQPSSTHDSP TATSPLKENS EVSCFTSDLS GPESRTISLE
   361  NCGFEGGGLL KRSAEKTDSS YFYRGDDQGK NLASREENEE RLLIPRSERG GPFLFNAREP
   421  EKEISGRCSG EKEPVVSPKE NIHNNCIQDS LHTGNSSSLM PNSFTEATEV MLNKNDLKIT
   481  VHVQGNLTNP EDHKETFTNM SHPGGHSEES SFSSLMQIEE AGQTTPVEPN ILSKSFYTKD
   541  CNSLVSIQRN LEGNTQLNEA SCNDFLFERK SIVSLMPEDQ ISPVSEVLKP KQGTALLLPS
   601  PEFDYRPESE KVIQTSHDDI PLLDEQSIAC EMNELSCTNE LVVNKVESEC VLNQQVSLNS
   661  QEHANLPTDS LLHLNKEMPL ATGRDAHQSH HPPLEGRADV IADIQTIPIQ TKIKDISPPG
   721  NQTCGASSNC PTLNIKPVSL ERKKEMADSG TKALHSRLRS NKREAAGFPQ VVSVIECHSV
   781  QSQDISSCHR VRKNVSQENM CSASAAFKSS KISLQVDNSL ITKYENAFQH RDHCCQGTGH
   841  SVEKSSCKVS YTSQERELDG KETNGSLPGD KIRNKMVAGL LNSGISNKTI HTSSSIKLSE
   901  EGLEGKEQDV SKETVFCKYN ISDHAIQELN QTVNIPGPEK VLDQSPTVMF SSFKNVKSVE
   961  TLDQKADEVL DCQSNQNRPD ECKSEGQSAK EMLSSDQRET VTEPHGEVNH NQKDLLVSSG
  1021  SNNSLPCGSP KKCNLKGAFV KMSGCDESTE GMVDIVYTDC SNKLAEGVLD VKASNLLDCG
  1081  ARQEKLAFQE DSRSTLSRRE LDAAHTGTTG QDSDFPVTAA STVDFLKIKK SCEENVCRSL
  1141  KDCEMEKCPD SCAHEMESVA DHEPNKRILG RVNLSLNDSH YGQQDKGTSL RETQEMTEGS
  1201  RLEPNSEFGK ESTFGISSKE SMSCHDESSV SLRSLKSIEI MPSQENSETN VNSEETDLKN
  1261  LCKPKDGEML CENVKDCTVL PEMKEIVSRD WSNSSDRDSV CTCVEKNACK ACHPHENSSD
  1321  RHLPLTVKTD IKVKGEETEE HQRGRLGYLT VGEQSEELVT RETGDGDPVS NISQTHFKCR
  1381  GILNHAEKQQ SPEVLDYMLQ KEEKYIRQQK AHTISQQCIS SSLLLDDAQN QNQPKADKDE
  1441  STMINEITLA KLAKDSIVAQ TQKLEDQKEE RLHHPLRKDT ESCTSPCLLG APRKAQDPSS
  1501  AGCDQIHGAF AKKGVLPLKK QPHRTCKKVS YQEQIIVGRK IGKIRSSAFL KSSSNPIPTK
  1561  AHRLLSLCTL SAPTRLEPET APTKSLVSHI PKQMSTPCHP LRSLNFRKTT KESALLNKLS
  1621  ILASKLAPAM KTQKLRYRRC SSELLPMAKS YKRLRYKRLL DGFSSSTEQL NPYLAASGWD
  1681  KRPNSKPMAL YSLESIKMTF IDLSNKMPSL LFGSEIFPVS FHVKSSSSDC TTESSRTFPE
  1741  HCAPARLALG EALQCPSQPP KWTFSFFLSH GCPGMATFRE DTGVHSQTHT QAPPQPPAPL
  1801  QDYGGTAIVQ TRADCSVLGL HTLLALCSPG CYRIWTKKRS FSSHMPTMQR LFMTQFTQGL
  1861  KGLRSPASIA DKVFCSLPYS VGRVLSIWSQ HGPSVCSFEI SSLHSPHCKR QPSLGTTSSH
  1921  TMLPYVPLPG MEATYNTSGS QTRLEPPFPA LVPKSCLVAE SAVSKLLLSA SEFQVRGLDE
  1981  LDGVKAACPC PQSSPPEQKE AEPEKRPKKV SQIRIRKTIP RPDPNLTPMG LPRPKRLKKK
  2041  EFSLEEIYTN KNYKSPPANR CLETIFEEPK ERNGTLISIS QQKRKRVLEF QDFTVPRKRR
  2101  ARGKVKVAGS FTRAQKAAVQ SRELDALLIQ KLMELETFFA KEEEQEQSSG C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR14L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 8.1 nTPM
thymus: 7.1 nTPM
tonsil: 6.8 nTPM
rectum: 6.6 nTPM
lymph node: 6.5 nTPM
skin: 6.5 nTPM

Single-cell type

choroid plexus epithelial cells: 146 nCPM
neutrophils: 142 nCPM
neutrophil progenitors: 128 nCPM
somatotrophs: 119 nCPM
renal collecting duct intercalated cells: 116 nCPM
thyrotrophs: 110 nCPM

Immune cell

non-classical monocyte: 12 nTPM
basophil: 9.1 nTPM
neutrophil: 8.1 nTPM
eosinophil: 5.4 nTPM
intermediate monocyte: 5.1 nTPM
classical monocyte: 4.3 nTPM

Brain region

choroid plexus: 40 nTPM
cerebellum: 34 nTPM
white matter: 34 nTPM
thalamus: 31 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 2.47
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR14L as an antibody target. Whether an autoantibody or antibody against PRR14L could matter depends on whether native PRR14L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR14L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR14L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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