Seroatlas · Human Serome Atlas

PRR13

Proline-rich protein 13

Also known as: DKFZP564J157, FLJ23818, PRR13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZ81
Gene
PRR13
Ensembl
ENSG00000205352
Chromosome
12
Canonical length
148 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>Q9NZ81|PRR13
     1  MWNPNAGQPG PNPYPPNIGC PGGSNPAHPP PINPPFPPGP CPPPPGAPHG NPAFPPGGPP
    61  HPVPQPGYPG CQPLGPYPPP YPPPAPGIPP VNPLAPGMVG PAVIVDKKMQ KKMKKAHKKM
   121  HKHQKHHKYH KHGKHSSSSS SSSSSDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
425 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 425 nTPM
  • small intestine: 407 nTPM
  • kidney: 394 nTPM
  • colon: 296 nTPM
  • bone marrow: 263 nTPM
  • rectum: 249 nTPM

Single-cell type

  • neutrophils: 50 nCPM
  • enterocytes: 44 nCPM
  • proximal tubule cells: 37 nCPM
  • distal convoluted tubule cells: 33 nCPM
  • oocytes: 32 nCPM
  • parietal cells: 32 nCPM

Immune cell

  • neutrophil: 2,107 nTPM
  • eosinophil: 1,625 nTPM
  • total PBMC: 1,574 nTPM
  • non-classical monocyte: 1,020 nTPM
  • intermediate monocyte: 943 nTPM
  • memory B-cell: 892 nTPM

Brain region

  • hypothalamus: 185 nTPM
  • midbrain: 156 nTPM
  • cerebral cortex: 148 nTPM
  • pons: 144 nTPM
  • medulla oblongata: 143 nTPM
  • thalamus: 128 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0.01
gnomAD missense Z
-0.41
DepMap mean gene effect
-0.51
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR13 as an antibody target. Whether an autoantibody or antibody against PRR13 could matter depends on whether native PRR13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRR13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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