Seroatlas · Human Serome Atlas

PRR11

Proline-rich protein 11

Also known as: FLJ11029, PRR11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HE9
Gene: PRR11
Ensembl: ENSG00000068489
Chromosome: 17
Canonical length: 360 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Involved in regulation of cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q96HE9|PRR11
     1  MPKFKQRRRK LKAKAERLFK KKEASHFQSK LITPPPPPPS PERVGISSID ISQSRSWLTS
    61  SWNFNFPNIR DAIKLWTNRV WSIYSWCQNC ITQSLEVLKD TIFPSRICHR ELYSVKQQFC
   121  ILESKLCKLQ EALKTISESS SCPSCGQTCH MSGKLTNVPA CVLITPGDSK AVLPPTLPQP
   181  ASHFPPPPPP PPLPPPPPPL APVLLRKPSL AKALQAGPLK KDGPMQITVK DLLTVKLKKT
   241  QSLDEKRKLI PSPKARNPLV TVSDLQHVTL KPNSKVLSTR VTNVLITPGK SQMDLRKLLR
   301  KVDVERSPGG TPLTNKENME TGTGLTPVMT QALRRKFQLA HPRSPTPTLP LSTSSFDEQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

thymus: 19 nTPM
bone marrow: 17 nTPM
tonsil: 11 nTPM
lymph node: 9.5 nTPM
appendix: 6.1 nTPM
duodenum: 6.1 nTPM

Single-cell type

monocyte progenitors: 44 nCPM
megakaryocyte progenitors: 41 nCPM
hematopoietic stem cells: 35 nCPM
erythrocyte progenitors: 26 nCPM
megakaryocyte-erythroid progenitors: 25 nCPM
neutrophil progenitors: 17 nCPM

Immune cell

non-classical monocyte: 9.6 nTPM
intermediate monocyte: 4 nTPM
myeloid DC: 2.6 nTPM
eosinophil: 2.3 nTPM
classical monocyte: 2 nTPM
neutrophil: 2 nTPM

Brain region

cerebellum: 18 nTPM
white matter: 16 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 13 nTPM
pons: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of cell cycle

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR11 as an antibody target. Whether an autoantibody or antibody against PRR11 could matter depends on whether native PRR11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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