Seroatlas · Human Serome Atlas

PRPF38B

Pre-mRNA-splicing factor 38B

Also known as: FLJ10330, NET1, PR38B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VTL8
Gene: PRPF38B
Ensembl: ENSG00000134186
Chromosome: 1
Canonical length: 546 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>Q5VTL8|PRPF38B
     1  MANNSPALTG NSQPQHQAAA AAAQQQQQCG GGGATKPAVS GKQGNVLPLW GNEKTMNLNP
    61  MILTNILSSP YFKVQLYELK TYHEVVDEIY FKVTHVEPWE KGSRKTAGQT GMCGGVRGVG
   121  TGGIVSTAFC LLYKLFTLKL TRKQVMGLIT HTDSPYIRAL GFMYIRYTQP PTDLWDWFES
   181  FLDDEEDLDV KAGGGCVMTI GEMLRSFLTK LEWFSTLFPR IPVPVQKNID QQIKTRPRKI
   241  KKDGKEGAEE IDRHVERRRS RSPRRSLSPR RSPRRSRSRS HHREGHGSSS FDRELEREKE
   301  RQRLEREAKE REKERRRSRS IDRGLERRRS RSRERHRSRS RSRDRKGDRR DRDREREKEN
   361  ERGRRRDRDY DKERGNEREK ERERSRERSK EQRSRGEVEE KKHKEDKDDR RHRDDKRDSK
   421  KEKKHSRSRS RERKHRSRSR SRNAGKRSRS RSKEKSSKHK NESKEKSNKR SRSGSQGRTD
   481  SVEKSKKREH SPSKEKSRKR SRSKERSHKR DHSDSKDQSD KHDRRRSQSI EQESQEKQHK
   541  NKDETV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRPF38B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 60 nTPM
cerebellum: 55 nTPM
lymph node: 43 nTPM
spleen: 42 nTPM
thymus: 35 nTPM
small intestine: 34 nTPM

Single-cell type

basal keratinocytes: 211 nCPM
neutrophils: 204 nCPM
suprabasal keratinocytes: 198 nCPM
t-cells: 196 nCPM
nk-cells: 185 nCPM
microglia: 167 nCPM

Immune cell

NK-cell: 32 nTPM
neutrophil: 30 nTPM
plasmacytoid DC: 28 nTPM
eosinophil: 27 nTPM
MAIT T-cell: 25 nTPM
T-reg: 25 nTPM

Brain region

cerebellum: 49 nTPM
medulla oblongata: 31 nTPM
white matter: 31 nTPM
hypothalamus: 31 nTPM
pons: 29 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.7
gnomAD missense Z: 1.92
DepMap mean gene effect: -1.77
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

precatalytic spliceosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRPF38B as an antibody target. Whether an autoantibody or antibody against PRPF38B could matter depends on whether native PRPF38B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRPF38B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRPF38B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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