Seroatlas · Human Serome Atlas

PROX2

Prospero homeobox protein 2

Also known as: FLJ36749, PROX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3B8N5
Gene: PROX2
Ensembl: ENSG00000119608
Chromosome: 14
Canonical length: 592 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

592 residues, UniProt reviewed canonical sequence.

>Q3B8N5|PROX2
     1  MDPNSILLSP QPQICSHLAE ACTEGERSSS PPELDRDSPF PWSQVPSSSP TDPEWFGDEH
    61  IQAKRARVET IVRGMCLSPN PLVPGNAQAG VSPRCPKKAR ERKRKQNLPT PQGLLMPAPA
   121  WDQGNRKGGP RVREQLHLLK QQLRHLQEHI LQAAKPRDTA QGPGGCGTGK GPLSAKQGNG
   181  CGPRPWVVDG DHQQGTSKDL SGAEKHQESE KPSFLPSGAP ASLEILRKEL TRAVSQAVDS
   241  VLQKVLLDPP GHLTQLGRSF QGQVAEGRSE PSPPVGGACK DPLALAALPR RVQLQAGVPV
   301  GNLSLAKRLD SPRYPIPPRM TPKPCQDPPA NFPLTAPSHI QENQILSQLL GHRYNNGHWS
   361  SSPPQDSSSQ RHPSSEPALR PWRTTKPQPL VLSQQQCPLP FTSAHLESLP LLPSVKMEQR
   421  GLHAVMEALP FSLLHIQEGL NPGHLKKAKL MFFFTRYPSS NLLKVYFPDV QFNRCITSQM
   481  IKWFSNFREF YYIQMEKSAR QAISDGVTNP KMLVVLRNSE LFQALNMHYN KGNDFEVPDC
   541  FLEIASLTLQ EFFRAVSAGR DSDPSWKKPI YKIISKLDSD IPEIFKSSSY PQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 2.3 nTPM
retina: 1.3 nTPM
skin: 1.1 nTPM
appendix: 1 nTPM
lymph node: 1 nTPM
spleen: 0.9 nTPM

Single-cell type

cardiomyocytes: 15 nCPM
microglia: 9.6 nCPM
thymocytes: 8.5 nCPM
epicardial cells: 6.8 nCPM
retinal amacrine cells: 5.6 nCPM
adipocytes: 5.1 nCPM

Immune cell

neutrophil: 11 nTPM
NK-cell: 1.5 nTPM
classical monocyte: 1.3 nTPM
eosinophil: 1.3 nTPM
intermediate monocyte: 1 nTPM
non-classical monocyte: 0.8 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 11 nTPM
choroid plexus: 10 nTPM
midbrain: 9.8 nTPM
cerebral cortex: 8.9 nTPM
thalamus: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROX2 as an antibody target. Whether an autoantibody or antibody against PROX2 could matter depends on whether native PROX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PROX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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