Seroatlas · Human Serome Atlas

PROSER3

Proline and serine-rich protein 3

Also known as: C19orf55, FLJ30657, PRSR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2NL68
Gene: PROSER3
Ensembl: ENSG00000167595
Chromosome: 19
Canonical length: 480 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>Q2NL68|PROSER3
     1  MDRSLPVFSI QDSPFGDAPL GRSHYWPSQS QTWCPKTLSP SRSQRSRLPQ APKALATGPN
    61  SPELFEESWP SSSGTPSLPS TTEGQMWASP APTLIDSGDS VVAKYINRFR QAQPTSREER
   121  QPAGPTPADF WWLQSDSPDP SSQSAAAGAN KPEGRPHTAV PTAVNVTSAS HAVAPLQEIK
   181  QNLHTWNSSL LDLETLSLQS RAARLLKRSK ASISSSSSLS PSDASTSSFP TSSDGLSPFS
   241  ETFIPDSSKG LGPRAPASPA PAQAQTPTPA PAPASSQAPL RPEDDILYQW RQRRKLEQAQ
   301  GSKGDRAWVP PLTPALRTLA ESLKAKALPP AAGSVIRKSE ATPSPGACLQ PEVPLSPAEQ
   361  ATTVKASPPA FQVGSPEALA PPPPAADHAP SEALLAQAAL LLQAAEDSDG SEFQDDPVLQ
   421  VLRAHRAELS RQKREADARL SFLLDQAEDL GSWSPPAGSP PRSPRRLLRR EGDSLEARRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROSER3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
skin: 7.4 nTPM
retina: 5.9 nTPM
bone marrow: 5.7 nTPM
pancreas: 5.7 nTPM
appendix: 5.6 nTPM

Single-cell type

respiratory ciliated cells: 52 nCPM
early spermatids: 40 nCPM
late spermatids: 33 nCPM
fallopian tube ciliated cells: 27 nCPM
hepatic stellate cells: 26 nCPM
rod photoreceptor cells: 26 nCPM

Immune cell

neutrophil: 10 nTPM
basophil: 6.6 nTPM
eosinophil: 3.4 nTPM
naive B-cell: 2.6 nTPM
memory B-cell: 2.4 nTPM
MAIT T-cell: 1.8 nTPM

Brain region

choroid plexus: 34 nTPM
medulla oblongata: 28 nTPM
white matter: 27 nTPM
cerebellum: 27 nTPM
cerebral cortex: 27 nTPM
amygdala: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

centrosome

Protein domainsUniProt · Pfam · InterPro

Proline and serine-rich protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROSER3 as an antibody target. Whether an autoantibody or antibody against PROSER3 could matter depends on whether native PROSER3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROSER3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PROSER3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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