Seroatlas · Human Serome Atlas

PROSER2

Proline and serine-rich protein 2

Also known as: C10orf47, MGC35403, PRSR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WR7
Gene: PROSER2
Ensembl: ENSG00000148426
Chromosome: 10
Canonical length: 435 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

No narrative summary is available for PROSER2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q86WR7|PROSER2
     1  MPVTHRKSDA SDMNSDTSPS CRLRAFSRGG SLESRSSSSR SRSFTLDDES LKYLTHEEKD
    61  VLLFFEETID SLDEDFEEPV LCDGGVCCLC SPSLEESTSS PSEPEDVIDL VQPAPGAGEA
   121  EGLPEGTQAA GPAPAGKEHR KQDAETPPPP DPPAPETLLA PPPLPSTPDP PRRELRAPSP
   181  PVEHPRLLRS VPTPLVMAQK ISERMAGNEA LSPTSPFREG RPGEWRTPAA RGPRSGDPGP
   241  GPSHPAQPKA PRFPSNIIVT NGAAREPRRT LSRAAVSVQE RRAQVLATIH GHAGAFPAAG
   301  DAGEGAPGGG SSPERVARGR GLPGPAESLR AGGQAPRGPA LANGFPSAHE ALKSAPSSFA
   361  PAGKSLCFRP GPALPSTRAR QSFPGPRQPN GAQDWRRADS LPRPQGITVQ FAGRGSSEEA
   421  RREALRKLGL LRESS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROSER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

liver: 40 nTPM
kidney: 13 nTPM
bone marrow: 9.8 nTPM
esophagus: 9.5 nTPM
lung: 9.4 nTPM
prostate: 8.6 nTPM

Single-cell type

loop of henle epithelial cells: 103 nCPM
hepatocytes: 96 nCPM
endometrial glandular cells: 93 nCPM
urothelial cells: 90 nCPM
endometrial luminal cells: 83 nCPM
alveolar cells type 1: 78 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
total PBMC: 0.2 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 9.9 nTPM
thalamus: 6.4 nTPM
midbrain: 4.6 nTPM
pons: 4.1 nTPM
basal ganglia: 4 nTPM
medulla oblongata: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -0.98
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Specifically androgen-regulated gene protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROSER2 as an antibody target. Whether an autoantibody or antibody against PROSER2 could matter depends on whether native PROSER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROSER2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PROSER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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