Seroatlas · Human Serome Atlas

PRORY

Proline-rich protein, Y-linked

Also known as: PRORY_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H606
Gene: PRORY
Canonical length: 182 aa

OverviewNCBI Gene

No narrative summary is available for PRORY in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q9H606|PRORY
     1  MMRRSPSGLK SPRVSQGRKP RDPESLLFLR CCLGSEPHNL SSLLSPEAGQ EPLPKLLPQP
    61  LAGHAAWGIH GVPTSLLLAG ECWGQGMAVP ADPPPASPYR TSPRPPPGPL PRYRPQQHLL
   121  LPLGRLHALC PGCPLQQSLQ FERGTLSAPR LWSWMKLETI ILSKLSQGQK TKHRMFSLIS
   181  ES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRORY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRORY as an antibody target. Whether an autoantibody or antibody against PRORY could matter depends on whether native PRORY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRORY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRORY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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