Seroatlas · Human Serome Atlas

PRORSD1P

Putative prolyl-tRNA synthetase associated domain-containing protein 1

Also known as: PRXD1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NEY8
Gene: PRORSD1P
Canonical length: 169 aa

OverviewNCBI Gene

No narrative summary is available for PRORSD1P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>A6NEY8|PRORSD1P
     1  MAGAELGAAL EQRLGALAIH TEVVEHPEVF TVEEMMPHIQ HLKGAHSKNL FLKDKKKKNY
    61  WLVTVLHDRQ INLNELAKQL GVGSGNLRFA DETAMLEKLK VGQGCATPLA LFCDGGDVKF
   121  VLDSAFLEGG HEKVYFHPMT NAATMGLSPE DFLTFVKMTG HDPIILNFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRORSD1P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

aminoacyl-tRNA deacylase activity

Protein domainsUniProt · Pfam · InterPro

YbaK/aminoacyl-tRNA synthetase-associated domain
YbaK/aminoacyl-tRNA synthetase-associated domain superfamily
Prolyl-tRNA editing protein ProX/PRXD1
Aminoacyl-tRNA editing domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRORSD1P as an antibody target. Whether an autoantibody or antibody against PRORSD1P could matter depends on whether native PRORSD1P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRORSD1P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRORSD1P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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