Seroatlas · Human Serome Atlas

PROM2

Prominin-2

Also known as: PROM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N271
Gene
PROM2
Ensembl
ENSG00000155066
Chromosome
2
Canonical length
834 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions,Mid piece,Principal piece,End piece,Annulus

OverviewNCBI Gene

This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

834 residues, UniProt reviewed canonical sequence.

>Q8N271|PROM2
     1  MKHTLALLAP LLGLGLGLAL SQLAAGATDC KFLGPAEHLT FTPAARARWL APRVRAPGLL
    61  DSLYGTVRRF LSVVQLNPFP SELVKALLNE LASVKVNEVV RYEAGYVVCA VIAGLYLLLV
   121  PTAGLCFCCC RCHRRCGGRV KTEHKALACE RAALMVFLLL TTLLLLIGVV CAFVTNQRTH
   181  EQMGPSIEAM PETLLSLWGL VSDVPQELQA VAQQFSLPQE QVSEELDGVG VSIGSAIHTQ
   241  LRSSVYPLLA AVGSLGQVLQ VSVHHLQTLN ATVVELQAGQ QDLEPAIREH RDRLLELLQE
   301  ARCQGDCAGA LSWARTLELG ADFSQVPSVD HVLHQLKGVP EANFSSMVQE ENSTFNALPA
   361  LAAMQTSSVV QELKKAVAQQ PEGVRTLAEG FPGLEAASRW AQALQEVEES SRPYLQEVQR
   421  YETYRWIVGC VLCSVVLFVV LCNLLGLNLG IWGLSARDDP SHPEAKGEAG ARFLMAGVGL
   481  SFLFAAPLIL LVFATFLVGG NVQTLVCQSW ENGELFEFAD TPGNLPPSMN LSQLLGLRKN
   541  ISIHQAYQQC KEGAALWTVL QLNDSYDLEE HLDINQYTNK LRQELQSLKV DTQSLDLLSS
   601  AARRDLEALQ SSGLQRIHYP DFLVQIQRPV VKTSMEQLAQ ELQGLAQAQD NSVLGQRLQE
   661  EAQGLRNLHQ EKVVPQQSLV AKLNLSVRAL ESSAPNLQLE TSDVLANVTY LKGELPAWAA
   721  RILRNVSECF LAREMGYFSQ YVAWVREEVT QRIATCQPLS GALDNSRVIL CDMMADPWNA
   781  FWFCLAWCTF FLIPSIIFAV KTSKYFRPIR KRLSSTSSEE TQLFHIPRVT SLKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 84 nTPM
  • skin: 57 nTPM
  • vagina: 37 nTPM
  • kidney: 34 nTPM
  • salivary gland: 34 nTPM
  • cervix: 31 nTPM

Single-cell type

  • esophageal apical cells: 201 nCPM
  • salivary duct cells: 179 nCPM
  • esophageal suprabasal cells: 137 nCPM
  • prostatic hillock cells: 106 nCPM
  • ocular epithelial cells: 88 nCPM
  • papillary tip epithelial cells: 87 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 7.4 nTPM
  • white matter: 7.2 nTPM
  • thalamus: 6.2 nTPM
  • medulla oblongata: 6.1 nTPM
  • basal ganglia: 5.7 nTPM
  • pons: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.92
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROM2 as an antibody target. Whether an autoantibody or antibody against PROM2 could matter depends on whether native PROM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROM2 is annotated at the cell surface, where native PROM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PROM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PROM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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