Seroatlas · Human Serome Atlas

PROK2

Prokineticin-2

Also known as: BV8, KAL4, MIT1, PK2, PROK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC23
Gene: PROK2
Ensembl: ENSG00000163421
Chromosome: 3
Canonical length: 129 aa
Protein class: Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

129 residues, UniProt reviewed canonical sequence.

>Q9HC23|PROK2
     1  MRSLCCAPLL LLLLLPPLLL TPRAGDAAVI TGACDKDSQC GGGMCCAVSI WVKSIRICTP
    61  MGKLGDSCHP LTRKNNFGNG RQERRKRKRS KRKKEVPFFG RRMHHTCPCL PGLACLRTSF
   121  NRFICLAQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 61 nTPM
spleen: 20 nTPM
appendix: 17 nTPM
lung: 12 nTPM
testis: 11 nTPM
adipose tissue: 6.7 nTPM

Single-cell type

neutrophils: 1,547 nCPM
neutrophil progenitors: 118 nCPM
monocyte progenitors: 88 nCPM
late primary spermatocytes: 54 nCPM
megakaryocyte-erythroid progenitors: 44 nCPM
monocytes: 36 nCPM

Immune cell

neutrophil: 416 nTPM
classical monocyte: 8.2 nTPM
naive CD8 T-cell: 5 nTPM
eosinophil: 3.5 nTPM
gdT-cell: 3.4 nTPM
total PBMC: 3.1 nTPM

Brain region

cerebral cortex: 31 nTPM
thalamus: 4.2 nTPM
pons: 3 nTPM
midbrain: 2.4 nTPM
amygdala: 1.8 nTPM
choroid plexus: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PROK2.

Disease | AllUniProt

Conditions PROK2 is implicated in, by any mechanism.

Hypogonadotropic hypogonadism 4 with or without anosmia (HH4) MIM:610628

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 93 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypogonadotropic hypogonadism 4 with or without anosmia
PROK2-related disorder
Male infertility with spermatogenesis disorder
Male infertility with azoospermia or oligozoospermia due to single gene mutation
Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0.01
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROK2 as an antibody target. Whether an autoantibody or antibody against PROK2 could matter depends on whether native PROK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROK2 is annotated as secreted, so native PROK2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PROK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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