PROK1
Prokineticin-1
Also known as: EGVEGF, PK1, PRK1, PROK1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P58294
- Gene
- PROK1
- Ensembl
- ENSG00000143125
- Chromosome
- 1
- Canonical length
- 105 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
105 residues, UniProt reviewed canonical sequence.
>P58294|PROK1
1 MRGATRVSIM LLLVTVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRMC TPLGREGEEC
61 HPGSHKVPFF RKRKHHTCPC LPNLLCSRFP DGRYRCSMDL KNINFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PROK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 191 nTPM
Expression across tissuesHPA
Tissue
- ovary: 191 nTPM
- testis: 56 nTPM
- placenta: 47 nTPM
- cervix: 29 nTPM
- vagina: 25 nTPM
- prostate: 12 nTPM
Single-cell type
- peritubular myoid cells: 620 nCPM
- leydig cells: 194 nCPM
- granulosa cells: 161 nCPM
- ovarian stromal cells: 82 nCPM
- decidual stromal cells: 16 nCPM
- endometrial stromal cells: 13 nCPM
Immune cell
- MAIT T-cell: 0.1 nTPM
- NK-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- medulla oblongata: 11 nTPM
- spinal cord: 3.2 nTPM
- white matter: 2.6 nTPM
- midbrain: 2.2 nTPM
- pons: 1.9 nTPM
- hippocampal formation: 1.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.19
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- angiogenesis
- endothelial cell proliferation
- positive regulation of cell division
- positive regulation of MAPK cascade
- positive regulation of vascular endothelial cell proliferation
- regulation of angiogenesis
- vascular endothelial cell proliferation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PROK1 as an antibody target. Whether an autoantibody or antibody against PROK1 could matter depends on whether native PROK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PROK1 is annotated as secreted, so native PROK1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label PROK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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